From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity
Sequence analyses highlight a massive peptide sharing between immunoreactive Epstein-Barr virus (EBV) epitopes and human proteins that—when mutated, deficient or improperly functioning—associate with tumorigenesis, diabetes, lupus, multiple sclerosis, rheumatoid arthritis, and immunodeficiencies, am...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2020-08-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1715641 |
| _version_ | 1811312943317385216 |
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| author | Darja Kanduc Yehuda Shoenfeld |
| author_facet | Darja Kanduc Yehuda Shoenfeld |
| author_sort | Darja Kanduc |
| collection | DOAJ |
| description | Sequence analyses highlight a massive peptide sharing between immunoreactive Epstein-Barr virus (EBV) epitopes and human proteins that—when mutated, deficient or improperly functioning—associate with tumorigenesis, diabetes, lupus, multiple sclerosis, rheumatoid arthritis, and immunodeficiencies, among others. Peptide commonality appears to be the molecular platform capable of linking EBV infection to the vast EBV-associated diseasome via cross-reactivity and questions the hypothesis of the “negative selection” of self-reactive lymphocytes. Of utmost importance, this study warns that using entire antigens in anti-EBV immunotherapies can associate with autoimmune manifestations and further supports the concept of peptide uniqueness for designing safe and effective anti-EBV immunotherapies. |
| first_indexed | 2024-04-13T10:45:31Z |
| format | Article |
| id | doaj.art-2ae62966b9d047f5837c1ff605634bb0 |
| institution | Directory Open Access Journal |
| issn | 2699-9404 |
| language | English |
| last_indexed | 2024-04-13T10:45:31Z |
| publishDate | 2020-08-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj.art-2ae62966b9d047f5837c1ff605634bb02022-12-22T02:49:48ZengGeorg Thieme Verlag KGGlobal Medical Genetics2699-94042020-08-01070205106310.1055/s-0040-1715641From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivityDarja Kanduc0Yehuda Shoenfeld1Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, ItalyZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, IsraelSequence analyses highlight a massive peptide sharing between immunoreactive Epstein-Barr virus (EBV) epitopes and human proteins that—when mutated, deficient or improperly functioning—associate with tumorigenesis, diabetes, lupus, multiple sclerosis, rheumatoid arthritis, and immunodeficiencies, among others. Peptide commonality appears to be the molecular platform capable of linking EBV infection to the vast EBV-associated diseasome via cross-reactivity and questions the hypothesis of the “negative selection” of self-reactive lymphocytes. Of utmost importance, this study warns that using entire antigens in anti-EBV immunotherapies can associate with autoimmune manifestations and further supports the concept of peptide uniqueness for designing safe and effective anti-EBV immunotherapies.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1715641ebv epitopessystemic lupus erythematosuscross-reactivityautoimmunitynegative selectionself-reactive lymphocytespathogenic autoantibodies |
| spellingShingle | Darja Kanduc Yehuda Shoenfeld From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity Global Medical Genetics ebv epitopes systemic lupus erythematosus cross-reactivity autoimmunity negative selection self-reactive lymphocytes pathogenic autoantibodies |
| title | From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity |
| title_full | From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity |
| title_fullStr | From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity |
| title_full_unstemmed | From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity |
| title_short | From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity |
| title_sort | from anti ebv immune responses to the ebv diseasome via cross reactivity |
| topic | ebv epitopes systemic lupus erythematosus cross-reactivity autoimmunity negative selection self-reactive lymphocytes pathogenic autoantibodies |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1715641 |
| work_keys_str_mv | AT darjakanduc fromantiebvimmuneresponsestotheebvdiseasomeviacrossreactivity AT yehudashoenfeld fromantiebvimmuneresponsestotheebvdiseasomeviacrossreactivity |