Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma.
<h4>Purpose</h4>To evaluate the risk factors associated with recurrent disc hemorrhage (DH), defined for the present study as at least 3 occurrences of DH in primary open-angle glaucoma (POAG).<h4>Methods</h4>A total of 178 POAG patients (89 eyes showing at least 3 occurrence...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0222166 |
| _version_ | 1818834513124392960 |
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| author | Bo Ram Seol Jin Wook Jeoung Ki Ho Park |
| author_facet | Bo Ram Seol Jin Wook Jeoung Ki Ho Park |
| author_sort | Bo Ram Seol |
| collection | DOAJ |
| description | <h4>Purpose</h4>To evaluate the risk factors associated with recurrent disc hemorrhage (DH), defined for the present study as at least 3 occurrences of DH in primary open-angle glaucoma (POAG).<h4>Methods</h4>A total of 178 POAG patients (89 eyes showing at least 3 occurrences of DH and 89 age-matched control eyes with a minimum of 10 years' follow-up without DH) were included in a retrospective, case-control study. Ocular factors were evaluated by a retrospective chart review, and systemic factors were evaluated by a telephone survey. Associations between factors and recurrent DH were investigated by logistic regression analysis. The Kaplan-Meier survival analysis and Cox proportional-hazards regression models were used to evaluate glaucoma progression and to identify the factors predictive of glaucoma progression.<h4>Results</h4>Univariate regression analysis revealed the association of recurrent DH with low baseline intraocular pressure (IOP) [odds ratio (OR), 0.88; 95% confidential interval (CI), 0.80-0.98; P = 0.014], lower percentage reduction of IOP (OR, 0.96; 95% CI, 0.93-0.99; P = 0.020), cold extremities (OR, 2.80; 95% CI, 1.03-7.60; P = 0.043), prone or lateral decubitus sleeping position (OR, 2.14; 95% CI, 1.13-4.03; P = 0.019), and sleeping disorders (OR, 2.33; 95% CI, 1.05-5.15; P = 0.037). Multivariate regression analysis revealed that a lower percentage reduction in IOP (OR, 0.96; 95% CI, 0.93-1.00; P = 0.046) increased the risk of recurrent DH. The control group exhibited a greater cumulative probability of non-progression than the recurrent DH group (P = 0.01, by log-rank test). The Cox proportional-hazards regression model showed that recurrent DH was associated with glaucoma progression [hazard ratio (HR), 1.88; 95% CI; 1.66-3.05; P = 0.01.<h4>Conclusions</h4>Among the ocular and systemic factors, only lower-percentage reduction of IOP in POAG was associated with recurrent DH. DH recurrence is associated with glaucoma progression and may be dependent on IOP. |
| first_indexed | 2024-12-19T02:36:00Z |
| format | Article |
| id | doaj.art-2ae677a9d2e342fa9669c481c886e0db |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T02:36:00Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2ae677a9d2e342fa9669c481c886e0db2022-12-21T20:39:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01149e022216610.1371/journal.pone.0222166Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma.Bo Ram SeolJin Wook JeoungKi Ho Park<h4>Purpose</h4>To evaluate the risk factors associated with recurrent disc hemorrhage (DH), defined for the present study as at least 3 occurrences of DH in primary open-angle glaucoma (POAG).<h4>Methods</h4>A total of 178 POAG patients (89 eyes showing at least 3 occurrences of DH and 89 age-matched control eyes with a minimum of 10 years' follow-up without DH) were included in a retrospective, case-control study. Ocular factors were evaluated by a retrospective chart review, and systemic factors were evaluated by a telephone survey. Associations between factors and recurrent DH were investigated by logistic regression analysis. The Kaplan-Meier survival analysis and Cox proportional-hazards regression models were used to evaluate glaucoma progression and to identify the factors predictive of glaucoma progression.<h4>Results</h4>Univariate regression analysis revealed the association of recurrent DH with low baseline intraocular pressure (IOP) [odds ratio (OR), 0.88; 95% confidential interval (CI), 0.80-0.98; P = 0.014], lower percentage reduction of IOP (OR, 0.96; 95% CI, 0.93-0.99; P = 0.020), cold extremities (OR, 2.80; 95% CI, 1.03-7.60; P = 0.043), prone or lateral decubitus sleeping position (OR, 2.14; 95% CI, 1.13-4.03; P = 0.019), and sleeping disorders (OR, 2.33; 95% CI, 1.05-5.15; P = 0.037). Multivariate regression analysis revealed that a lower percentage reduction in IOP (OR, 0.96; 95% CI, 0.93-1.00; P = 0.046) increased the risk of recurrent DH. The control group exhibited a greater cumulative probability of non-progression than the recurrent DH group (P = 0.01, by log-rank test). The Cox proportional-hazards regression model showed that recurrent DH was associated with glaucoma progression [hazard ratio (HR), 1.88; 95% CI; 1.66-3.05; P = 0.01.<h4>Conclusions</h4>Among the ocular and systemic factors, only lower-percentage reduction of IOP in POAG was associated with recurrent DH. DH recurrence is associated with glaucoma progression and may be dependent on IOP.https://doi.org/10.1371/journal.pone.0222166 |
| spellingShingle | Bo Ram Seol Jin Wook Jeoung Ki Ho Park Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. PLoS ONE |
| title | Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. |
| title_full | Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. |
| title_fullStr | Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. |
| title_full_unstemmed | Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. |
| title_short | Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma. |
| title_sort | ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open angle glaucoma |
| url | https://doi.org/10.1371/journal.pone.0222166 |
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