miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
MicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.565266/full |
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| author | Bingqing Chen Bingqing Chen Zhibin Liao Zhibin Liao Yongqiang Qi Yongqiang Qi Hongwei Zhang Hongwei Zhang Chen Su Chen Su Huifang Liang Huifang Liang Bixiang Zhang Bixiang Zhang Bixiang Zhang Xiaoping Chen Xiaoping Chen Xiaoping Chen |
| author_facet | Bingqing Chen Bingqing Chen Zhibin Liao Zhibin Liao Yongqiang Qi Yongqiang Qi Hongwei Zhang Hongwei Zhang Chen Su Chen Su Huifang Liang Huifang Liang Bixiang Zhang Bixiang Zhang Bixiang Zhang Xiaoping Chen Xiaoping Chen Xiaoping Chen |
| author_sort | Bingqing Chen |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631 is significantly down-regulated in HCC tissue compared with that in adjacent non-cancerous tissue, and low expression of miR-631 in HCC tissue is associated with cirrhosis, multiple tumors, incomplete tumor encapsulation, poor tumor differentiation, and high TNM stage. Our test results showed that miR-631 could inhibit migration, invasion, epithelial–mesenchymal transition (EMT) and intrahepatic metastasis of HCC. Receptor-type protein tyrosine phosphatase epsilon (PTPRE) as a downstream target of miR-631 could promote migration, invasion and EMT of HCC cells. Besides, the expression of PTPRE had a negative correlation with the expression of miR-631 both in vivo and in vitro, and increasing expression of PTPRE could reverse inhibitory effects of miR-631 in HCC cells. In sum, our study first demonstrated that miR-631 targeted PTPRE to inhibit intrahepatic metastasis in HCC. We gain insights from these findings into the mechanism of miRNAs regulation in HCC metastasis and further introduce a novel therapeutic target for HCC treatment. |
| first_indexed | 2024-12-20T01:08:13Z |
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| id | doaj.art-2ae77fd70dcb410eb48c4a94f2bdf799 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-20T01:08:13Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2ae77fd70dcb410eb48c4a94f2bdf7992022-12-21T19:58:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.565266565266miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPREBingqing Chen0Bingqing Chen1Zhibin Liao2Zhibin Liao3Yongqiang Qi4Yongqiang Qi5Hongwei Zhang6Hongwei Zhang7Chen Su8Chen Su9Huifang Liang10Huifang Liang11Bixiang Zhang12Bixiang Zhang13Bixiang Zhang14Xiaoping Chen15Xiaoping Chen16Xiaoping Chen17Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaKey Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Science and Technology Department of Hubei Province, Wuhan, ChinaKey Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaMicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631 is significantly down-regulated in HCC tissue compared with that in adjacent non-cancerous tissue, and low expression of miR-631 in HCC tissue is associated with cirrhosis, multiple tumors, incomplete tumor encapsulation, poor tumor differentiation, and high TNM stage. Our test results showed that miR-631 could inhibit migration, invasion, epithelial–mesenchymal transition (EMT) and intrahepatic metastasis of HCC. Receptor-type protein tyrosine phosphatase epsilon (PTPRE) as a downstream target of miR-631 could promote migration, invasion and EMT of HCC cells. Besides, the expression of PTPRE had a negative correlation with the expression of miR-631 both in vivo and in vitro, and increasing expression of PTPRE could reverse inhibitory effects of miR-631 in HCC cells. In sum, our study first demonstrated that miR-631 targeted PTPRE to inhibit intrahepatic metastasis in HCC. We gain insights from these findings into the mechanism of miRNAs regulation in HCC metastasis and further introduce a novel therapeutic target for HCC treatment.https://www.frontiersin.org/articles/10.3389/fonc.2020.565266/fullmiR-631receptor-type protein tyrosine phosphatase epsilontumor suppressorhepatocellular carcinomaintrahepatic metastasis |
| spellingShingle | Bingqing Chen Bingqing Chen Zhibin Liao Zhibin Liao Yongqiang Qi Yongqiang Qi Hongwei Zhang Hongwei Zhang Chen Su Chen Su Huifang Liang Huifang Liang Bixiang Zhang Bixiang Zhang Bixiang Zhang Xiaoping Chen Xiaoping Chen Xiaoping Chen miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE Frontiers in Oncology miR-631 receptor-type protein tyrosine phosphatase epsilon tumor suppressor hepatocellular carcinoma intrahepatic metastasis |
| title | miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE |
| title_full | miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE |
| title_fullStr | miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE |
| title_full_unstemmed | miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE |
| title_short | miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE |
| title_sort | mir 631 inhibits intrahepatic metastasis of hepatocellular carcinoma by targeting ptpre |
| topic | miR-631 receptor-type protein tyrosine phosphatase epsilon tumor suppressor hepatocellular carcinoma intrahepatic metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.565266/full |
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