Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis
<p>Abstract</p> <p>Background</p> <p>It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum l...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/10/1/54 |
| _version_ | 1811311898394624000 |
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| author | Xu Wenbing Wang Juan Gui Yaosong Feng Ruie Zhou Jiong Wang Lan Xu Kai-Feng Luo Jinmei Tian Xinlun Xiao Yi Zhu Yuanjue |
| author_facet | Xu Wenbing Wang Juan Gui Yaosong Feng Ruie Zhou Jiong Wang Lan Xu Kai-Feng Luo Jinmei Tian Xinlun Xiao Yi Zhu Yuanjue |
| author_sort | Xu Wenbing |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.</p> <p>Methods and Results</p> <p>Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (<it>P</it><sub>25</sub>: 104.36, <it>P</it><sub>75</sub>: 219.00) <it>vs </it>119.56 mg/dl (<it>P</it><sub>25</sub>: 78.81, <it>P</it><sub>75</sub>: 193.03), <it>P </it>< 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 <it>vs </it>51.34 ± 12.06 mg/dl, <it>P </it>< 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO<sub>2 </sub>(r = -0.403, <it>P </it>< 0.05) and positively with lactate dehydrogenase (r = 0.381, <it>P </it>< 0.05).</p> <p>Conclusions</p> <p>PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.</p> |
| first_indexed | 2024-04-13T10:26:54Z |
| format | Article |
| id | doaj.art-2ae8239f67a943e788fda81bdfd4de77 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-13T10:26:54Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-2ae8239f67a943e788fda81bdfd4de772022-12-22T02:50:16ZengBMCLipids in Health and Disease1476-511X2011-04-011015410.1186/1476-511X-10-54Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosisXu WenbingWang JuanGui YaosongFeng RuieZhou JiongWang LanXu Kai-FengLuo JinmeiTian XinlunXiao YiZhu Yuanjue<p>Abstract</p> <p>Background</p> <p>It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.</p> <p>Methods and Results</p> <p>Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (<it>P</it><sub>25</sub>: 104.36, <it>P</it><sub>75</sub>: 219.00) <it>vs </it>119.56 mg/dl (<it>P</it><sub>25</sub>: 78.81, <it>P</it><sub>75</sub>: 193.03), <it>P </it>< 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 <it>vs </it>51.34 ± 12.06 mg/dl, <it>P </it>< 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO<sub>2 </sub>(r = -0.403, <it>P </it>< 0.05) and positively with lactate dehydrogenase (r = 0.381, <it>P </it>< 0.05).</p> <p>Conclusions</p> <p>PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.</p>http://www.lipidworld.com/content/10/1/54high-density lipoprotein cholesterollipidpulmonary alveolar proteinosistriglyceride |
| spellingShingle | Xu Wenbing Wang Juan Gui Yaosong Feng Ruie Zhou Jiong Wang Lan Xu Kai-Feng Luo Jinmei Tian Xinlun Xiao Yi Zhu Yuanjue Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis Lipids in Health and Disease high-density lipoprotein cholesterol lipid pulmonary alveolar proteinosis triglyceride |
| title | Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| title_full | Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| title_fullStr | Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| title_full_unstemmed | Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| title_short | Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| title_sort | impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis |
| topic | high-density lipoprotein cholesterol lipid pulmonary alveolar proteinosis triglyceride |
| url | http://www.lipidworld.com/content/10/1/54 |
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