Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives
Bioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1378473/full |
| _version_ | 1797221814782394368 |
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| author | Silvia V. Conde Joana F. Sacramento Ciro Zinno Alberto Mazzoni Silvestro Micera Maria P. Guarino |
| author_facet | Silvia V. Conde Joana F. Sacramento Ciro Zinno Alberto Mazzoni Silvestro Micera Maria P. Guarino |
| author_sort | Silvia V. Conde |
| collection | DOAJ |
| description | Bioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngeal nerve that connects the carotid body (CB) to the brain, restores metabolic function in type 2 diabetes (T2D) animal models highlighting its potential as a new therapeutic modality to treat metabolic diseases in humans. In this manuscript, we review the current knowledge supporting the use of neuromodulation of the CSN to treat T2D and discuss the future perspectives for its clinical application. Firstly, we review in a concise manner the role of CB chemoreceptors and of CSN in the pathogenesis of metabolic diseases. Secondly, we describe the findings supporting the potential therapeutic use of the neuromodulation of CSN to treat T2D, as well as the feasibility and reversibility of this approach. A third section is devoted to point up the advances in the neural decoding of CSN activity, in particular in metabolic disease states, that will allow the development of closed-loop approaches to deliver personalized and adjustable treatments with minimal side effects. And finally, we discuss the findings supporting the assessment of CB activity in metabolic disease patients to screen the individuals that will benefit therapeutically from this bioelectronic approach in the future. |
| first_indexed | 2024-04-24T13:11:25Z |
| format | Article |
| id | doaj.art-2ae912510df34a5ebcb55ac4032e89f3 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-24T13:11:25Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2ae912510df34a5ebcb55ac4032e89f32024-04-05T04:30:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-04-011810.3389/fnins.2024.13784731378473Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectivesSilvia V. Conde0Joana F. Sacramento1Ciro Zinno2Alberto Mazzoni3Silvestro Micera4Maria P. Guarino5iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, PortugaliNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, PortugalThe BioRobotics Institute Scuola Superiore Sant’Anna, Pontedera, ItalyThe BioRobotics Institute Scuola Superiore Sant’Anna, Pontedera, ItalyThe BioRobotics Institute Scuola Superiore Sant’Anna, Pontedera, ItalyciTechCare, School of Health Sciences Polytechnic of Leiria, Leiria, PortugalBioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngeal nerve that connects the carotid body (CB) to the brain, restores metabolic function in type 2 diabetes (T2D) animal models highlighting its potential as a new therapeutic modality to treat metabolic diseases in humans. In this manuscript, we review the current knowledge supporting the use of neuromodulation of the CSN to treat T2D and discuss the future perspectives for its clinical application. Firstly, we review in a concise manner the role of CB chemoreceptors and of CSN in the pathogenesis of metabolic diseases. Secondly, we describe the findings supporting the potential therapeutic use of the neuromodulation of CSN to treat T2D, as well as the feasibility and reversibility of this approach. A third section is devoted to point up the advances in the neural decoding of CSN activity, in particular in metabolic disease states, that will allow the development of closed-loop approaches to deliver personalized and adjustable treatments with minimal side effects. And finally, we discuss the findings supporting the assessment of CB activity in metabolic disease patients to screen the individuals that will benefit therapeutically from this bioelectronic approach in the future.https://www.frontiersin.org/articles/10.3389/fnins.2024.1378473/fullbioelectronic medicinecarotid bodycarotid sinus nerveneuromodulationtype 2 diabetes |
| spellingShingle | Silvia V. Conde Joana F. Sacramento Ciro Zinno Alberto Mazzoni Silvestro Micera Maria P. Guarino Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives Frontiers in Neuroscience bioelectronic medicine carotid body carotid sinus nerve neuromodulation type 2 diabetes |
| title | Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives |
| title_full | Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives |
| title_fullStr | Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives |
| title_full_unstemmed | Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives |
| title_short | Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives |
| title_sort | bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes current knowledge and future perspectives |
| topic | bioelectronic medicine carotid body carotid sinus nerve neuromodulation type 2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1378473/full |
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