High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

Aldosterone synthase is the key rate‐limiting enzyme in adrenal aldosterone production, and induction of its gene (CYP11B2) results in the progression of hypertension. As hypertension is a frequent complication among patients with diabetes, we set out to elucidate the link between diabetes mellitus...

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Bibliographic Details
Main Authors: Hiroki Shimada, Naotaka Kogure, Erika Noro, Masataka Kudo, Kaori Sugawara, Ikuko Sato, Kyoko Shimizu, Makoto Kobayashi, Dai Suzuki, Rehana Parvin, Takako Saito‐Ito, Akira Uruno, Akiko Saito‐Hakoda, William E. Rainey, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:FEBS Open Bio
Subjects:
aldosterone synthase
diabetes mellitus
hypertension
NURR1
Online Access:https://doi.org/10.1002/2211-5463.12277

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