Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma
In this report we describe a case of pulmonary epithelioid hemangioendothelioma (PEH) in a young woman. The neoplasm manifested with dry cough, chest pain, finger clubbing, and multiple bilateral pulmonary nodules on chest x-ray and computed tomographic (CT) scan. She underwent thoracoscopy, and the...
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| Format: | Article |
| Language: | English |
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De Gruyter
2016-01-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2016-0025 |
| _version_ | 1818731324632989696 |
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| author | Calabrese Cecilia Gilli Marina De Rosa Nicolina Di Crescenzo Vincenzo Zeppa Pio Vitale Carolina Vatrella Alessandro |
| author_facet | Calabrese Cecilia Gilli Marina De Rosa Nicolina Di Crescenzo Vincenzo Zeppa Pio Vitale Carolina Vatrella Alessandro |
| author_sort | Calabrese Cecilia |
| collection | DOAJ |
| description | In this report we describe a case of pulmonary epithelioid hemangioendothelioma (PEH) in a young woman. The neoplasm manifested with dry cough, chest pain, finger clubbing, and multiple bilateral pulmonary nodules on chest x-ray and computed tomographic (CT) scan. She underwent thoracoscopy, and the histological features of the lung biopsies were initially interpreted as consistent with a not-well-defined interstitial lung disease. Our patient was clinically and radiologically stable over a period of four years, after which the disease progressed to involve not only the lung but also mediastinal lymph nodes, liver and bone. Fiberoptic bronchoscopy showed subtotal occlusion of the right middle and lower lobe bronchi. The histologic examination of bronchial biopsies revealed a poorly differentiated neoplasm immunohistochemically positive for vimentin and vascular markers CD31, CD34 and Factor VIII. A diagnosis of malignant hemangioendothelioma was made. Positron emission tomography (PET) is more sensitive than CT scan and bone scintigraphy in detecting PEH metastases. Furthermore, 18-fluorodeoxyglucose (FDG) uptake seems to be related to the grade of malignancy of PEH lesions. Therefore, we suggest that FDG-PET should be included in the staging system and follow-up of PEH. |
| first_indexed | 2024-12-17T23:15:52Z |
| format | Article |
| id | doaj.art-2aea3d7ef5a5461e9023fb9ec287c8a9 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-17T23:15:52Z |
| publishDate | 2016-01-01 |
| publisher | De Gruyter |
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| series | Open Medicine |
| spelling | doaj.art-2aea3d7ef5a5461e9023fb9ec287c8a92022-12-21T21:29:01ZengDe GruyterOpen Medicine2391-54632016-01-0111115816210.1515/med-2016-0025med-2016-0025Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendotheliomaCalabrese Cecilia0Gilli Marina1De Rosa Nicolina2Di Crescenzo Vincenzo3Zeppa Pio4Vitale Carolina5Vatrella Alessandro6Department of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, ItalyDepartment of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, ItalyAORN Ospedale dei Colli, Division of Pulmonary Oncology, Naples, ItalyAORN Ospedale dei Colli, Division of Pathology, Naples, ItalyAORN Ospedale dei Colli, Division of Pathology, Naples, ItalyAORN Ospedale dei Colli, Division of Pathology, Naples, ItalyUniversity of Salerno, Department of Medicine and Surgery, Baronissi Campus, Via S. Allende, Baronissi (SA), ItalyIn this report we describe a case of pulmonary epithelioid hemangioendothelioma (PEH) in a young woman. The neoplasm manifested with dry cough, chest pain, finger clubbing, and multiple bilateral pulmonary nodules on chest x-ray and computed tomographic (CT) scan. She underwent thoracoscopy, and the histological features of the lung biopsies were initially interpreted as consistent with a not-well-defined interstitial lung disease. Our patient was clinically and radiologically stable over a period of four years, after which the disease progressed to involve not only the lung but also mediastinal lymph nodes, liver and bone. Fiberoptic bronchoscopy showed subtotal occlusion of the right middle and lower lobe bronchi. The histologic examination of bronchial biopsies revealed a poorly differentiated neoplasm immunohistochemically positive for vimentin and vascular markers CD31, CD34 and Factor VIII. A diagnosis of malignant hemangioendothelioma was made. Positron emission tomography (PET) is more sensitive than CT scan and bone scintigraphy in detecting PEH metastases. Furthermore, 18-fluorodeoxyglucose (FDG) uptake seems to be related to the grade of malignancy of PEH lesions. Therefore, we suggest that FDG-PET should be included in the staging system and follow-up of PEH.https://doi.org/10.1515/med-2016-0025ct-scanfdg-petpulmonary epithelioid hemangioendotheliomalung cancer staging |
| spellingShingle | Calabrese Cecilia Gilli Marina De Rosa Nicolina Di Crescenzo Vincenzo Zeppa Pio Vitale Carolina Vatrella Alessandro Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma Open Medicine ct-scan fdg-pet pulmonary epithelioid hemangioendothelioma lung cancer staging |
| title | Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma |
| title_full | Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma |
| title_fullStr | Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma |
| title_full_unstemmed | Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma |
| title_short | Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma |
| title_sort | role of fdg pet scan in staging of pulmonary epithelioid hemangioendothelioma |
| topic | ct-scan fdg-pet pulmonary epithelioid hemangioendothelioma lung cancer staging |
| url | https://doi.org/10.1515/med-2016-0025 |
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