Chromosome Abnormalities in Turkish Men with Primary Infertility
OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility. STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control...
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| Format: | Article |
| Language: | English |
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Medical Network
2010-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/332 |
| _version_ | 1797916485118590976 |
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| author | Tayfun Güngör Mine Kanat Pektaş Müfit Günel Leyla Mollamahmutoğlu |
| author_facet | Tayfun Güngör Mine Kanat Pektaş Müfit Günel Leyla Mollamahmutoğlu |
| author_sort | Tayfun Güngör |
| collection | DOAJ |
| description | OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility.
STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group.
RESULTS: Azoospermia is defined to be the most frequent spermiogram abnormality within infertile men, followed by oligoasthenoteratozoospermia. Chromosomal abnormalities were demonstrated to occur significantly more in azoospermic subjects (28.3%) compared to other infertile subjects (11.5%) and fertile men (0.8%). Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%. Azoospermia Factor (AZF) microdeletions occur statistically similar among azoospermic men (4.2%) and other infertile men (2.3%), with a total frequency of 3.2%.
CONCLUSION: The high rate of chromosomal anomalies among infertile Turkish men strongly suggests the need for routine cytogenetic analysis prior to the application of assisted reproduction techniques. |
| first_indexed | 2024-04-10T12:59:11Z |
| format | Article |
| id | doaj.art-2aecb7242db94189a9806ac1c86a57ab |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T12:59:11Z |
| publishDate | 2010-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-2aecb7242db94189a9806ac1c86a57ab2023-02-15T16:13:18ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512010-04-01161264Chromosome Abnormalities in Turkish Men with Primary InfertilityTayfun Güngör0Mine Kanat Pektaş1Müfit Günel2Leyla Mollamahmutoğlu3Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, AnkaraDr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, AnkaraDr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Andrology, AnkaraDr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Infertility, AnkaraOBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility. STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group. RESULTS: Azoospermia is defined to be the most frequent spermiogram abnormality within infertile men, followed by oligoasthenoteratozoospermia. Chromosomal abnormalities were demonstrated to occur significantly more in azoospermic subjects (28.3%) compared to other infertile subjects (11.5%) and fertile men (0.8%). Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%. Azoospermia Factor (AZF) microdeletions occur statistically similar among azoospermic men (4.2%) and other infertile men (2.3%), with a total frequency of 3.2%. CONCLUSION: The high rate of chromosomal anomalies among infertile Turkish men strongly suggests the need for routine cytogenetic analysis prior to the application of assisted reproduction techniques.http://gorm.com.tr/index.php/GORM/article/view/332Azoospermia, Chromosomal abnormality, Klinefelter syndrome, Male infertility, Spermiogram |
| spellingShingle | Tayfun Güngör Mine Kanat Pektaş Müfit Günel Leyla Mollamahmutoğlu Chromosome Abnormalities in Turkish Men with Primary Infertility Gynecology Obstetrics & Reproductive Medicine Azoospermia, Chromosomal abnormality, Klinefelter syndrome, Male infertility, Spermiogram |
| title | Chromosome Abnormalities in Turkish Men with Primary Infertility |
| title_full | Chromosome Abnormalities in Turkish Men with Primary Infertility |
| title_fullStr | Chromosome Abnormalities in Turkish Men with Primary Infertility |
| title_full_unstemmed | Chromosome Abnormalities in Turkish Men with Primary Infertility |
| title_short | Chromosome Abnormalities in Turkish Men with Primary Infertility |
| title_sort | chromosome abnormalities in turkish men with primary infertility |
| topic | Azoospermia, Chromosomal abnormality, Klinefelter syndrome, Male infertility, Spermiogram |
| url | http://gorm.com.tr/index.php/GORM/article/view/332 |
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