Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury
INTRODUCTION: kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. W...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2016-05-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/24/54/pdf/54.pdf
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| author | Mildred Zulu Trevor Kaile Timothy Kantenga Chisanga Chileshe Panji Nkhoma Musalula Sinkala |
| author_facet | Mildred Zulu Trevor Kaile Timothy Kantenga Chisanga Chileshe Panji Nkhoma Musalula Sinkala |
| author_sort | Mildred Zulu |
| collection | DOAJ |
| description | INTRODUCTION: kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of kidney injury, in comparison with creatinine. METHODS: we compared the levels of urine MAU, urine KIM-1 and other plasma biochemical tests in specimens from 80 individuals with and without kidney disease. RESULTS: we found no difference in KIM-1 levels between the kidney disease group (2.82, 1.36ng/mL) and controls (3.29 , 1.14ng/mL), p = 0.122. MAU was higher in participants with kidney disease (130.809 84.744 /mL) than the controls (15.983,20.442 g/mL), p =0.001. KIM-1 showed a weak negative correlation with creatinine (r = -0.279, p = 0.09), whereas MAU was positively correlated with creatinine in participants with kidney disease with statistical significance (r = 0.556, p = 0.001). CONCLUSION: the study demonstrated that in Zambian setting MAU and creatinine are sensitive biomarkers in the diagnosis of kidney damage. We moreover propose further evaluation of KIM-1 as a biomarker of kidney injury. |
| first_indexed | 2024-12-19T22:30:43Z |
| format | Article |
| id | doaj.art-2aecdcd52e4c4eca9a7b5e596d5b4f36 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-19T22:30:43Z |
| publishDate | 2016-05-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-2aecdcd52e4c4eca9a7b5e596d5b4f362022-12-21T20:03:20ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882016-05-01245410.11604/pamj.2016.24.54.87598759Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injuryMildred Zulu0Trevor Kaile1Timothy Kantenga2Chisanga Chileshe3Panji Nkhoma4Musalula Sinkala5 University of Zambia, School of Medicine, Department of Pathology and Microbiology, Lusaka, Zambia University of Zambia, School of Medicine, Department of Pathology and Microbiology, Lusaka, Zambia University Teaching Hospital, Department of Pathology and Microbiology, Lusaka, Zambia University of Zambia, School of Medicine, KS-HHV8 Research and Diagnostic Laboratory, Lusaka, Zambia University of Zambia, School of Medicine, Department of Biomedical Sciences, Lusaka, Zambia University of Zambia, School of Medicine, Department of Biomedical Sciences, Lusaka, Zambia INTRODUCTION: kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of kidney injury, in comparison with creatinine. METHODS: we compared the levels of urine MAU, urine KIM-1 and other plasma biochemical tests in specimens from 80 individuals with and without kidney disease. RESULTS: we found no difference in KIM-1 levels between the kidney disease group (2.82, 1.36ng/mL) and controls (3.29 , 1.14ng/mL), p = 0.122. MAU was higher in participants with kidney disease (130.809 84.744 /mL) than the controls (15.983,20.442 g/mL), p =0.001. KIM-1 showed a weak negative correlation with creatinine (r = -0.279, p = 0.09), whereas MAU was positively correlated with creatinine in participants with kidney disease with statistical significance (r = 0.556, p = 0.001). CONCLUSION: the study demonstrated that in Zambian setting MAU and creatinine are sensitive biomarkers in the diagnosis of kidney damage. We moreover propose further evaluation of KIM-1 as a biomarker of kidney injury. https://www.panafrican-med-journal.com/content/article/24/54/pdf/54.pdf kidney injury molecule-1microalbumincreatinineureakidney disease |
| spellingShingle | Mildred Zulu Trevor Kaile Timothy Kantenga Chisanga Chileshe Panji Nkhoma Musalula Sinkala Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury The Pan African Medical Journal kidney injury molecule-1 microalbumin creatinine urea kidney disease |
| title | Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury |
| title_full | Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury |
| title_fullStr | Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury |
| title_full_unstemmed | Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury |
| title_short | Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury |
| title_sort | kidney injury molecule 1 and microalbuminuria levels in zambian population biomarkers of kidney injury |
| topic | kidney injury molecule-1 microalbumin creatinine urea kidney disease |
| url |
https://www.panafrican-med-journal.com/content/article/24/54/pdf/54.pdf
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