Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535221005384 |
| _version_ | 1819174372394401792 |
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| author | Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge |
| author_facet | Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge |
| author_sort | Zhisheng Liu |
| collection | DOAJ |
| description | In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques like ICP-OES, FE-SEM, EDX, atomic mapping, TEM, VSM, and XRD studies. In the antioxidant test, the IC50 of Fe3O4/PEG2000/Cu nanocomposite and BHT against DPPH free radicals were 198 and 85 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Fe3O4/PEG2000/Cu nanocomposite were assessed by MTT assay for 48 h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of Fe3O4/PEG2000/Cu nanocomposite were 316 and 131 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Fe3O4/PEG2000/Cu nanocomposite. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects. |
| first_indexed | 2024-12-22T20:37:55Z |
| format | Article |
| id | doaj.art-2aece31e92834668b5a87fa4878c8152 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-22T20:37:55Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-2aece31e92834668b5a87fa4878c81522022-12-21T18:13:25ZengElsevierArabian Journal of Chemistry1878-53522022-01-01151103523Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigationZhisheng Liu0Kai Wang1Tingting Wang2Ye Wang3Yunjie Ge4Department of General Surgery, Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266033, ChinaDepartment of General Surgery, Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266033, ChinaDepartment of General Surgery, Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266033, ChinaDepartment of General Surgery, Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266033, ChinaDepartment of Healthcare Internal Medicine, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong 266000, China; Corresponding author.In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques like ICP-OES, FE-SEM, EDX, atomic mapping, TEM, VSM, and XRD studies. In the antioxidant test, the IC50 of Fe3O4/PEG2000/Cu nanocomposite and BHT against DPPH free radicals were 198 and 85 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Fe3O4/PEG2000/Cu nanocomposite were assessed by MTT assay for 48 h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of Fe3O4/PEG2000/Cu nanocomposite were 316 and 131 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Fe3O4/PEG2000/Cu nanocomposite. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects.http://www.sciencedirect.com/science/article/pii/S1878535221005384PEGCu nanoparticlesNonmagneticHuman gastric cancerAntioxidant |
| spellingShingle | Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation Arabian Journal of Chemistry PEG Cu nanoparticles Nonmagnetic Human gastric cancer Antioxidant |
| title | Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation |
| title_full | Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation |
| title_fullStr | Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation |
| title_full_unstemmed | Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation |
| title_short | Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation |
| title_sort | copper nanoparticles supported on polyethylene glycol modified magnetic fe3o4 nanoparticles its anti human gastric cancer investigation |
| topic | PEG Cu nanoparticles Nonmagnetic Human gastric cancer Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S1878535221005384 |
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