CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system. This clinically heterogeneous neurological disorder is closely related to Guillain–Barré syndrome and is considered the chronic counterpart of that acute di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Immuno |
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| Online Access: | https://www.mdpi.com/2673-5601/2/1/9 |
| _version_ | 1827648513270349824 |
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| author | Susana Brun Jérôme de Sèze Sylviane Muller |
| author_facet | Susana Brun Jérôme de Sèze Sylviane Muller |
| author_sort | Susana Brun |
| collection | DOAJ |
| description | Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system. This clinically heterogeneous neurological disorder is closely related to Guillain–Barré syndrome and is considered the chronic counterpart of that acute disease. Currently available treatments are mostly empirical; they include corticosteroids, intravenous immunoglobulins, plasma exchange and chronic immunosuppressive agents, either alone or in combination. Recent advances in the understanding of the underlying pathogenic mechanisms in CIDP have brought a number of novel ways of possible intervention for use in CIDP. This review summarizes selected pre-clinical and clinical findings, highlights the importance of using adapted animal models to evaluate the efficacy of novel treatments, and proposes the outlines of future directions to ameliorate the conditions of patients with CIDP. |
| first_indexed | 2024-03-09T19:40:16Z |
| format | Article |
| id | doaj.art-2aedc468855e42ad85d7b4da05a12cd3 |
| institution | Directory Open Access Journal |
| issn | 2673-5601 |
| language | English |
| last_indexed | 2024-03-09T19:40:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj.art-2aedc468855e42ad85d7b4da05a12cd32023-11-24T01:40:21ZengMDPI AGImmuno2673-56012022-01-012111813110.3390/immuno2010009CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic InterventionSusana Brun0Jérôme de Sèze1Sylviane Muller2CNRS-Strasbourg University Biotechnology and Cell Signaling UMR7242/Strasbourg Drug Discovery and Development Institute (IMS), 67000 Strasbourg, FranceCentre d’Investigation Clinique INSERM 1434, University Hospital of Strasbourg, and Biopathology of Myelin, Neuroprotection and Therapeutic Strategies, INSERM U1119, 67000 Strasbourg, FranceCNRS-Strasbourg University Biotechnology and Cell Signaling UMR7242/Strasbourg Drug Discovery and Development Institute (IMS), 67000 Strasbourg, FranceChronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system. This clinically heterogeneous neurological disorder is closely related to Guillain–Barré syndrome and is considered the chronic counterpart of that acute disease. Currently available treatments are mostly empirical; they include corticosteroids, intravenous immunoglobulins, plasma exchange and chronic immunosuppressive agents, either alone or in combination. Recent advances in the understanding of the underlying pathogenic mechanisms in CIDP have brought a number of novel ways of possible intervention for use in CIDP. This review summarizes selected pre-clinical and clinical findings, highlights the importance of using adapted animal models to evaluate the efficacy of novel treatments, and proposes the outlines of future directions to ameliorate the conditions of patients with CIDP.https://www.mdpi.com/2673-5601/2/1/9chronic inflammatory demyelinating polyneuropathyperipheral nervespathogenesispathologymechanismsautophagy |
| spellingShingle | Susana Brun Jérôme de Sèze Sylviane Muller CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention Immuno chronic inflammatory demyelinating polyneuropathy peripheral nerves pathogenesis pathology mechanisms autophagy |
| title | CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention |
| title_full | CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention |
| title_fullStr | CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention |
| title_full_unstemmed | CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention |
| title_short | CIDP: Current Treatments and Identification of Targets for Future Specific Therapeutic Intervention |
| title_sort | cidp current treatments and identification of targets for future specific therapeutic intervention |
| topic | chronic inflammatory demyelinating polyneuropathy peripheral nerves pathogenesis pathology mechanisms autophagy |
| url | https://www.mdpi.com/2673-5601/2/1/9 |
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