Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent
Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2020-02-01
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| Series: | Case Reports in Neurology |
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| Online Access: | https://www.karger.com/Article/FullText/505232 |
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| author | Ismail Ibrahim Ismail John K. John Mohamed Ibrahim Jasem Yousef Al-Hashel |
| author_facet | Ismail Ibrahim Ismail John K. John Mohamed Ibrahim Jasem Yousef Al-Hashel |
| author_sort | Ismail Ibrahim Ismail |
| collection | DOAJ |
| description | Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to the best of our knowledge. We report a case of PLE in a 19-year-old male patient secondary to thymoma that was diagnosed after 5 years of onset. Anti-CV2/CRMP5 antibodies were positive in the serum and became negative after thymectomy. Diagnosis of PNS should be evoked in cases with atypical neurological manifestation and can be confirmed by the presence of onconeuronal antibodies. We report the first pediatric PLE secondary to thymoma associated with anti-CV2/CRMP5 antibodies. |
| first_indexed | 2024-12-21T16:59:04Z |
| format | Article |
| id | doaj.art-2aef3551d80d47e69d3c57446b5bfb8d |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-12-21T16:59:04Z |
| publishDate | 2020-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-2aef3551d80d47e69d3c57446b5bfb8d2022-12-21T18:56:41ZengKarger PublishersCase Reports in Neurology1662-680X2020-02-01121505510.1159/000505232505232Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an AdolescentIsmail Ibrahim IsmailJohn K. JohnMohamed IbrahimJasem Yousef Al-HashelParaneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to the best of our knowledge. We report a case of PLE in a 19-year-old male patient secondary to thymoma that was diagnosed after 5 years of onset. Anti-CV2/CRMP5 antibodies were positive in the serum and became negative after thymectomy. Diagnosis of PNS should be evoked in cases with atypical neurological manifestation and can be confirmed by the presence of onconeuronal antibodies. We report the first pediatric PLE secondary to thymoma associated with anti-CV2/CRMP5 antibodies.https://www.karger.com/Article/FullText/505232limbic encephalitisonconeuronal antibodiescv2crmp5paraneoplastic syndromesthymoma |
| spellingShingle | Ismail Ibrahim Ismail John K. John Mohamed Ibrahim Jasem Yousef Al-Hashel Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent Case Reports in Neurology limbic encephalitis onconeuronal antibodies cv2 crmp5 paraneoplastic syndromes thymoma |
| title | Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent |
| title_full | Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent |
| title_fullStr | Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent |
| title_full_unstemmed | Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent |
| title_short | Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent |
| title_sort | paraneoplastic limbic encephalitis associated with anti cv2 crmp5 antibodies secondary to thymoma in an adolescent |
| topic | limbic encephalitis onconeuronal antibodies cv2 crmp5 paraneoplastic syndromes thymoma |
| url | https://www.karger.com/Article/FullText/505232 |
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