Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection
Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important for Mtb pathogenicity: the cell wall, the lipoarab...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/6/999 |
| _version_ | 1797595797862219776 |
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| author | Alice Italia Mohammed Monsoor Shaik Francesco Peri |
| author_facet | Alice Italia Mohammed Monsoor Shaik Francesco Peri |
| author_sort | Alice Italia |
| collection | DOAJ |
| description | Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important for Mtb pathogenicity: the cell wall, the lipoarabinomannan, and the secretory proteins. Within the cell wall, we further focus on three biopolymeric sub-components: mycolic acids, arabinogalactan, and peptidoglycan. We present a comprehensive overview of drugs and drug candidates that target cell walls, envelopes, and secretory systems. An understanding at a molecular level of Mtb pathogenesis is provided, and potential future directions in therapeutic strategies are suggested to access new drugs to combat the growing global threat of antibiotic-resistant Mtb infection. |
| first_indexed | 2024-03-11T02:41:33Z |
| format | Article |
| id | doaj.art-2af06f43941a4d5993c8fa578faecd83 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:41:33Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-2af06f43941a4d5993c8fa578faecd832023-11-18T09:31:44ZengMDPI AGBiomolecules2218-273X2023-06-0113699910.3390/biom13060999Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb InfectionAlice Italia0Mohammed Monsoor Shaik1Francesco Peri2Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, ItalyEmerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important for Mtb pathogenicity: the cell wall, the lipoarabinomannan, and the secretory proteins. Within the cell wall, we further focus on three biopolymeric sub-components: mycolic acids, arabinogalactan, and peptidoglycan. We present a comprehensive overview of drugs and drug candidates that target cell walls, envelopes, and secretory systems. An understanding at a molecular level of Mtb pathogenesis is provided, and potential future directions in therapeutic strategies are suggested to access new drugs to combat the growing global threat of antibiotic-resistant Mtb infection.https://www.mdpi.com/2218-273X/13/6/999infectious diseasestuberculosisdrug developmentvirulence factorsimmune system |
| spellingShingle | Alice Italia Mohammed Monsoor Shaik Francesco Peri Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection Biomolecules infectious diseases tuberculosis drug development virulence factors immune system |
| title | Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection |
| title_full | Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection |
| title_fullStr | Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection |
| title_full_unstemmed | Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection |
| title_short | Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection |
| title_sort | emerging extracellular molecular targets for innovative pharmacological approaches to resistant mtb infection |
| topic | infectious diseases tuberculosis drug development virulence factors immune system |
| url | https://www.mdpi.com/2218-273X/13/6/999 |
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