Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice
ABSTRACT: Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia were studied in mice. Buspirone did not affect plasma glucose levels of non-fasted mice, while it increased serum insulin levels. In fasted mice, buspirone significantly reduced glucose-ind...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2003-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319325587 |
| _version_ | 1818970855441432576 |
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| author | Yumi Sugimoto Nozomu Takashima Toshiko Noma Jun Yamada |
| author_facet | Yumi Sugimoto Nozomu Takashima Toshiko Noma Jun Yamada |
| author_sort | Yumi Sugimoto |
| collection | DOAJ |
| description | ABSTRACT: Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia were studied in mice. Buspirone did not affect plasma glucose levels of non-fasted mice, while it increased serum insulin levels. In fasted mice, buspirone significantly reduced glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. This suggests that buspirone enhances insulin release, resulting in inhibition of glucose-induced hyperglycemia. The major metabolite of buspirone, 1-(2-pyrimidinyl)piperazine (1-PP) increased serum insulin levels and induced a slight hypoglycemia in non-fasted mice. 1-PP decreases glucose-induced hyperglycemia and amplifies insulin release elicited by glucose in fasted mice. Since buspirone is mainly metabolized to 1-PP and formation of 1-PP occurs quickly, the inhibitory effect of buspirone on glucose-induced hyperglycemia is likely mediated by 1-PP. |
| first_indexed | 2024-12-20T14:43:07Z |
| format | Article |
| id | doaj.art-2af290db643a49519ca9fb5aeadf94c5 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-20T14:43:07Z |
| publishDate | 2003-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-2af290db643a49519ca9fb5aeadf94c52022-12-21T19:37:12ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01934446450Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in MiceYumi Sugimoto0Nozomu Takashima1Toshiko Noma2Jun Yamada3Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, JapanDepartment of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, JapanDepartment of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, JapanDepartment of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, JapanABSTRACT: Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia were studied in mice. Buspirone did not affect plasma glucose levels of non-fasted mice, while it increased serum insulin levels. In fasted mice, buspirone significantly reduced glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. This suggests that buspirone enhances insulin release, resulting in inhibition of glucose-induced hyperglycemia. The major metabolite of buspirone, 1-(2-pyrimidinyl)piperazine (1-PP) increased serum insulin levels and induced a slight hypoglycemia in non-fasted mice. 1-PP decreases glucose-induced hyperglycemia and amplifies insulin release elicited by glucose in fasted mice. Since buspirone is mainly metabolized to 1-PP and formation of 1-PP occurs quickly, the inhibitory effect of buspirone on glucose-induced hyperglycemia is likely mediated by 1-PP.http://www.sciencedirect.com/science/article/pii/S1347861319325587 |
| spellingShingle | Yumi Sugimoto Nozomu Takashima Toshiko Noma Jun Yamada Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice Journal of Pharmacological Sciences |
| title | Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice |
| title_full | Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice |
| title_fullStr | Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice |
| title_full_unstemmed | Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice |
| title_short | Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice |
| title_sort | effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose induced hyperglycemia in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319325587 |
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