Neurogenesis and the Effect of Antidepressants
The recent evidence that neurogenesis occurs throughout adulthood and neural stem cells (NSCs) reside in the adult central nervous system (CNS) suggests that the CNS has the potential for self-repair. Beside this potential, the function of newly generated neuronal cells in the adult brain remains th...
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| Format: | Article |
| Language: | English |
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AboutScience Srl
2006-01-01
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| Series: | Drug Target Insights |
| Online Access: | https://doi.org/10.1177/117739280600100005 |
| _version_ | 1818269223667892224 |
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| author | Philippe Taupin |
| author_facet | Philippe Taupin |
| author_sort | Philippe Taupin |
| collection | DOAJ |
| description | The recent evidence that neurogenesis occurs throughout adulthood and neural stem cells (NSCs) reside in the adult central nervous system (CNS) suggests that the CNS has the potential for self-repair. Beside this potential, the function of newly generated neuronal cells in the adult brain remains the focus of intense research. The hippocampus of patients with depression show signs of atrophy and neuronal loss. This suggests that adult neurogenesis may contribute to the biology of depression. The observations that antidepressants, like fluoxetine, increase neurogenesis in the dentate gyrus (DG) and neurogenesis is required for the behavioral effect of antidepressants, lead to a new theory for depression and the design of new strategies and drugs for the treatment of depression. However, the role of adult neurogenesis in the etiology of depression remains the source of controversies and debates. |
| first_indexed | 2024-12-12T20:50:58Z |
| format | Article |
| id | doaj.art-2af2a518aeaa4176a3262db1719ee199 |
| institution | Directory Open Access Journal |
| issn | 1177-3928 |
| language | English |
| last_indexed | 2024-12-12T20:50:58Z |
| publishDate | 2006-01-01 |
| publisher | AboutScience Srl |
| record_format | Article |
| series | Drug Target Insights |
| spelling | doaj.art-2af2a518aeaa4176a3262db1719ee1992022-12-22T00:12:26ZengAboutScience SrlDrug Target Insights1177-39282006-01-01110.1177/117739280600100005Neurogenesis and the Effect of AntidepressantsPhilippe Taupin0Nanyang Technological University, Singapore.The recent evidence that neurogenesis occurs throughout adulthood and neural stem cells (NSCs) reside in the adult central nervous system (CNS) suggests that the CNS has the potential for self-repair. Beside this potential, the function of newly generated neuronal cells in the adult brain remains the focus of intense research. The hippocampus of patients with depression show signs of atrophy and neuronal loss. This suggests that adult neurogenesis may contribute to the biology of depression. The observations that antidepressants, like fluoxetine, increase neurogenesis in the dentate gyrus (DG) and neurogenesis is required for the behavioral effect of antidepressants, lead to a new theory for depression and the design of new strategies and drugs for the treatment of depression. However, the role of adult neurogenesis in the etiology of depression remains the source of controversies and debates.https://doi.org/10.1177/117739280600100005 |
| spellingShingle | Philippe Taupin Neurogenesis and the Effect of Antidepressants Drug Target Insights |
| title | Neurogenesis and the Effect of Antidepressants |
| title_full | Neurogenesis and the Effect of Antidepressants |
| title_fullStr | Neurogenesis and the Effect of Antidepressants |
| title_full_unstemmed | Neurogenesis and the Effect of Antidepressants |
| title_short | Neurogenesis and the Effect of Antidepressants |
| title_sort | neurogenesis and the effect of antidepressants |
| url | https://doi.org/10.1177/117739280600100005 |
| work_keys_str_mv | AT philippetaupin neurogenesisandtheeffectofantidepressants |