Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort
Background/Aim: Elevation in liver enzymes and hepatic fat may indicate a higher susceptibility to cardiovascular disease (CVD). This research sought to find anthropometric/biochemical variables significantly related to the alanine aminotransferase (ALT) increase in healthy populations. Methods: Nin...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2023-01-01
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| Series: | Scripta Medica |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292304353H.pdf |
| _version_ | 1797366933111177216 |
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| author | Han Youngmin Yoo Hye Jin Kim Yeri Huang Ximei Lee Jong Ho Kim Minjoo |
| author_facet | Han Youngmin Yoo Hye Jin Kim Yeri Huang Ximei Lee Jong Ho Kim Minjoo |
| author_sort | Han Youngmin |
| collection | DOAJ |
| description | Background/Aim: Elevation in liver enzymes and hepatic fat may indicate a higher susceptibility to cardiovascular disease (CVD). This research sought to find anthropometric/biochemical variables significantly related to the alanine aminotransferase (ALT) increase in healthy populations. Methods: Nine hundred healthy subjects were included in a 3-year prospective cohort study. The initial screening revealed that 538 were found to be nondiabetic (fasting glucose < 126 mg/dL) and had normal ALT levels. Among them, 79 individuals with slightly elevated ALT levels after three years were assigned to the elevated ALT group. Of the remaining 459 participants, 241 subjects matched to the increased ALT group were the control group. Results: After three years of follow-up, individuals with elevated ALT showed notably higher aspartate aminotransferase (AST), ALT, gamma-glutamyl-transferase (g-GT), high sensitivity C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2 ) activity, oxidised low-density lipoprotein (ox-LDL), urinary 8-epi-prostaglandin F2a (8-epi-PGF2a) levels and brachial-ankle pulse wave velocity (ba-PWV) in comparison to the control group. Changes (D) in ALT showed a positive correlation with D AST, D gammaGT, D hs-CRP, D Lp-PLA2 activity, D ox-LDL, D urinary 8-epi-PGF2a and D ba-PWV. Furthermore, a direct positive link was observed between the D Lp-PLA2 activity and D AST, D ox-LDL and D ba-PWV. Conclusion: Increased Lp-PLA2 activity and other CVD risk indicators were observed to have a pronounced association with elevated ALT levels. This mild ALT elevation could potentially contribute to chronic low-grade inflammation. |
| first_indexed | 2024-03-08T17:11:35Z |
| format | Article |
| id | doaj.art-2af34de97ce347a79e86b4d317d93c93 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-03-08T17:11:35Z |
| publishDate | 2023-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-2af34de97ce347a79e86b4d317d93c932024-01-03T21:38:03ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542023-01-0154435336110.5937/scriptamed54-458692490-33292304353HChanges in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohortHan Youngmin0Yoo Hye Jin1Kim Yeri2Huang Ximei3Lee Jong Ho4Kim Minjoo5Yonsei University, Graduate School of Public Health, Institute for Health Promotion, Seoul, the Republic of KoreaInha University, Institute for Specialised Teaching and Research (INSTAR), Incheon, the Republic of KoreaYonsei University, College of Human Ecology, Department of Food and Nutrition, National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Seoul, the Republic of KoreaHannam University, College of Life Science and Nano Technology, Department of Food and Nutrition, Daejeon, the Republic of KoreaYonsei University, College of Human Ecology, Department of Food and Nutrition, National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Seoul, the Republic of KoreaHannam University, College of Life Science and Nano Technology, Department of Food and Nutrition, Daejeon, the Republic of KoreaBackground/Aim: Elevation in liver enzymes and hepatic fat may indicate a higher susceptibility to cardiovascular disease (CVD). This research sought to find anthropometric/biochemical variables significantly related to the alanine aminotransferase (ALT) increase in healthy populations. Methods: Nine hundred healthy subjects were included in a 3-year prospective cohort study. The initial screening revealed that 538 were found to be nondiabetic (fasting glucose < 126 mg/dL) and had normal ALT levels. Among them, 79 individuals with slightly elevated ALT levels after three years were assigned to the elevated ALT group. Of the remaining 459 participants, 241 subjects matched to the increased ALT group were the control group. Results: After three years of follow-up, individuals with elevated ALT showed notably higher aspartate aminotransferase (AST), ALT, gamma-glutamyl-transferase (g-GT), high sensitivity C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2 ) activity, oxidised low-density lipoprotein (ox-LDL), urinary 8-epi-prostaglandin F2a (8-epi-PGF2a) levels and brachial-ankle pulse wave velocity (ba-PWV) in comparison to the control group. Changes (D) in ALT showed a positive correlation with D AST, D gammaGT, D hs-CRP, D Lp-PLA2 activity, D ox-LDL, D urinary 8-epi-PGF2a and D ba-PWV. Furthermore, a direct positive link was observed between the D Lp-PLA2 activity and D AST, D ox-LDL and D ba-PWV. Conclusion: Increased Lp-PLA2 activity and other CVD risk indicators were observed to have a pronounced association with elevated ALT levels. This mild ALT elevation could potentially contribute to chronic low-grade inflammation.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292304353H.pdfalanine aminotransferaselp-pla 2 activityinflammationarterial stiffnessba-pw |
| spellingShingle | Han Youngmin Yoo Hye Jin Kim Yeri Huang Ximei Lee Jong Ho Kim Minjoo Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort Scripta Medica alanine aminotransferase lp-pla 2 activity inflammation arterial stiffness ba-pw |
| title | Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort |
| title_full | Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort |
| title_fullStr | Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort |
| title_full_unstemmed | Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort |
| title_short | Changes in Lp-PLA 2 are associated with elevated alanine aminotransferase levels: A nested case-control study in a three-year prospective cohort |
| title_sort | changes in lp pla 2 are associated with elevated alanine aminotransferase levels a nested case control study in a three year prospective cohort |
| topic | alanine aminotransferase lp-pla 2 activity inflammation arterial stiffness ba-pw |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292304353H.pdf |
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