How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020
Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lac...
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/514 |
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| author | Jacqueline Trouillas Marie-Lise Jaffrain-Rea Alexandre Vasiljevic Gérald Raverot Federico Roncaroli Chiara Villa |
| author_facet | Jacqueline Trouillas Marie-Lise Jaffrain-Rea Alexandre Vasiljevic Gérald Raverot Federico Roncaroli Chiara Villa |
| author_sort | Jacqueline Trouillas |
| collection | DOAJ |
| description | Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lactotroph, somatotroph and thyrotroph (PIT1 lineage), corticotroph (TPIT lineage) or gonadotroph (SF1 lineage), null cell or immunonegative tumor and plurihormonal tumors. The WHO 2017 classification suggested that subtypes, such as male lactotroph, silent corticotroph and Crooke cell, sparsely granulated somatotroph, and silent plurihormonal PIT1 positive tumors, should be considered as “high risk” tumors. However, the prognostic impact of these subtypes and of each morphologic type remains controversial. In contrast, the French five-tiered classification, taking into account the invasion, the immuno-histochemical (IHC) type, and the proliferative markers (Ki-67 index, mitotic count, p53 positivity), has a prognostic value validated by statistical analysis in 4 independent cohorts. A standardized report for the diagnosis of pituitary tumors, integrating all these parameters, has been proposed by the European Pituitary Pathology Group (EPPG). In 2020, the pituitary pathologist must be considered as a member of the multidisciplinary pituitary team. The pathological diagnosis may help the clinician to adapt the post-operative management, including appropriate follow-up and early recognition and treatment of potentially aggressive forms. |
| first_indexed | 2024-03-12T08:06:38Z |
| format | Article |
| id | doaj.art-2af61fe8f5ea418280729c12c58527aa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T08:06:38Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2af61fe8f5ea418280729c12c58527aa2023-09-02T19:27:56ZengMDPI AGCancers2072-66942020-02-0112251410.3390/cancers12020514cancers12020514How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020Jacqueline Trouillas0Marie-Lise Jaffrain-Rea1Alexandre Vasiljevic2Gérald Raverot3Federico Roncaroli4Chiara Villa5University of Lyon 1, University of Lyon, F-69000 Lyon, FranceBiotechnological and Applied Clinical Sciences Department, University of L’Aquila, 67100 L’Aquila, ItalyUniversity of Lyon 1, University of Lyon, F-69000 Lyon, FranceUniversity of Lyon 1, University of Lyon, F-69000 Lyon, FranceDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, Manchester M13 3PL, UKPathological Department, Foch Hospital, 40 rue Worth Suresnes, 92151 Suresnes, FranceAdenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lactotroph, somatotroph and thyrotroph (PIT1 lineage), corticotroph (TPIT lineage) or gonadotroph (SF1 lineage), null cell or immunonegative tumor and plurihormonal tumors. The WHO 2017 classification suggested that subtypes, such as male lactotroph, silent corticotroph and Crooke cell, sparsely granulated somatotroph, and silent plurihormonal PIT1 positive tumors, should be considered as “high risk” tumors. However, the prognostic impact of these subtypes and of each morphologic type remains controversial. In contrast, the French five-tiered classification, taking into account the invasion, the immuno-histochemical (IHC) type, and the proliferative markers (Ki-67 index, mitotic count, p53 positivity), has a prognostic value validated by statistical analysis in 4 independent cohorts. A standardized report for the diagnosis of pituitary tumors, integrating all these parameters, has been proposed by the European Pituitary Pathology Group (EPPG). In 2020, the pituitary pathologist must be considered as a member of the multidisciplinary pituitary team. The pathological diagnosis may help the clinician to adapt the post-operative management, including appropriate follow-up and early recognition and treatment of potentially aggressive forms.https://www.mdpi.com/2072-6694/12/2/514pituitary adenomapituitary tumorclassification of pituitary neuroendocrine tumorsclassification of pituitary tumors |
| spellingShingle | Jacqueline Trouillas Marie-Lise Jaffrain-Rea Alexandre Vasiljevic Gérald Raverot Federico Roncaroli Chiara Villa How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 Cancers pituitary adenoma pituitary tumor classification of pituitary neuroendocrine tumors classification of pituitary tumors |
| title | How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 |
| title_full | How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 |
| title_fullStr | How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 |
| title_full_unstemmed | How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 |
| title_short | How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020 |
| title_sort | how to classify pituitary neuroendocrine tumors pitnet s in 2020 |
| topic | pituitary adenoma pituitary tumor classification of pituitary neuroendocrine tumors classification of pituitary tumors |
| url | https://www.mdpi.com/2072-6694/12/2/514 |
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