Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens
Purpose: The axial elongation in myopia is associated with some structural and functional retinal changes. The purpose of this study was to investigate the effect of a contact lens (CL) intended for myopia control on the choroidal thickness (ChT) and the retinal electrical response. Methods: Ten myo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/11/3618 |
| _version_ | 1797597287876132864 |
|---|---|
| author | Ana Amorim-de-Sousa Jaume Pauné Sara Silva-Leite Paulo Fernandes José Manuel Gozález-Méijome António Queirós |
| author_facet | Ana Amorim-de-Sousa Jaume Pauné Sara Silva-Leite Paulo Fernandes José Manuel Gozález-Méijome António Queirós |
| author_sort | Ana Amorim-de-Sousa |
| collection | DOAJ |
| description | Purpose: The axial elongation in myopia is associated with some structural and functional retinal changes. The purpose of this study was to investigate the effect of a contact lens (CL) intended for myopia control on the choroidal thickness (ChT) and the retinal electrical response. Methods: Ten myopic eyes (10 subjects, 18–35 years of age) with spherical equivalents from −0.75 to −6.00 diopters (D) were enrolled. The ChT at different eccentricities (3 mm temporal, 1.5 mm temporal, sub-foveal ChT, 1.5 mm nasal, and 3 mm nasal), the photopic 3.0 b-wave of ffERG and the PERG were recorded and compared with two material-matched contact lenses following 30 min of wear: a single-vision CL (SV) and a radial power gradient CL with +1.50 D addition (PG). Results: Compared with the SV, the PG increased the ChT at all eccentricities, with statistically significant differences at 3.0 mm temporal (10.30 ± 11.51 µm, <i>p</i> = 0.020), in sub-foveal ChT (17.00 ± 20.01 µm, <i>p</i> = 0.025), and at 1.5 mm nasal (10.70 ± 14.50 µm, <i>p</i> = 0.044). The PG decreased significantly the SV amplitude of the ffERG photopic b-wave (11.80 (30.55) µV, <i>p</i> = 0.047), N35-P50 (0.90 (0.96) µV, <i>p</i> = 0.017), and P50-N95 (0.46 (2.50) µV, <i>p</i> = 0.047). The amplitude of the a-wave was negatively correlated with the ChT at 3.0T (r = −0.606, <i>p</i> = 0.038) and 1.5T (r = −0.748, <i>p</i> = 0.013), and the amplitude of the b-wave showed a negative correlation with the ChT at 1.5T (r = −0.693, <i>p</i> = 0.026). Conclusions: The PG increased the ChT in a similar magnitude observed in previous studies. These CLs attenuated the amplitude of the retinal response, possibly due to the combined effect of the induced peripheral defocus high-order aberrations impacting the central retinal image. The decrease in the response of bipolar and ganglion cells suggests a potential retrograde feedback signaling effect from the inner to outer retinal layers observed in previous studies. |
| first_indexed | 2024-03-11T03:04:24Z |
| format | Article |
| id | doaj.art-2af635f9bf9a405b9bfd9a9eccc34fd7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:04:24Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2af635f9bf9a405b9bfd9a9eccc34fd72023-11-18T08:04:06ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011211361810.3390/jcm12113618Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact LensAna Amorim-de-Sousa0Jaume Pauné1Sara Silva-Leite2Paulo Fernandes3José Manuel Gozález-Méijome4António Queirós5Clinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, PortugalTeknon Medical Center, 08022 Barcelona, SpainClinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, PortugalClinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, PortugalClinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, PortugalClinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, PortugalPurpose: The axial elongation in myopia is associated with some structural and functional retinal changes. The purpose of this study was to investigate the effect of a contact lens (CL) intended for myopia control on the choroidal thickness (ChT) and the retinal electrical response. Methods: Ten myopic eyes (10 subjects, 18–35 years of age) with spherical equivalents from −0.75 to −6.00 diopters (D) were enrolled. The ChT at different eccentricities (3 mm temporal, 1.5 mm temporal, sub-foveal ChT, 1.5 mm nasal, and 3 mm nasal), the photopic 3.0 b-wave of ffERG and the PERG were recorded and compared with two material-matched contact lenses following 30 min of wear: a single-vision CL (SV) and a radial power gradient CL with +1.50 D addition (PG). Results: Compared with the SV, the PG increased the ChT at all eccentricities, with statistically significant differences at 3.0 mm temporal (10.30 ± 11.51 µm, <i>p</i> = 0.020), in sub-foveal ChT (17.00 ± 20.01 µm, <i>p</i> = 0.025), and at 1.5 mm nasal (10.70 ± 14.50 µm, <i>p</i> = 0.044). The PG decreased significantly the SV amplitude of the ffERG photopic b-wave (11.80 (30.55) µV, <i>p</i> = 0.047), N35-P50 (0.90 (0.96) µV, <i>p</i> = 0.017), and P50-N95 (0.46 (2.50) µV, <i>p</i> = 0.047). The amplitude of the a-wave was negatively correlated with the ChT at 3.0T (r = −0.606, <i>p</i> = 0.038) and 1.5T (r = −0.748, <i>p</i> = 0.013), and the amplitude of the b-wave showed a negative correlation with the ChT at 1.5T (r = −0.693, <i>p</i> = 0.026). Conclusions: The PG increased the ChT in a similar magnitude observed in previous studies. These CLs attenuated the amplitude of the retinal response, possibly due to the combined effect of the induced peripheral defocus high-order aberrations impacting the central retinal image. The decrease in the response of bipolar and ganglion cells suggests a potential retrograde feedback signaling effect from the inner to outer retinal layers observed in previous studies.https://www.mdpi.com/2077-0383/12/11/3618myopia controlcontact lenschoroidal thicknessERGretinal activity |
| spellingShingle | Ana Amorim-de-Sousa Jaume Pauné Sara Silva-Leite Paulo Fernandes José Manuel Gozález-Méijome António Queirós Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens Journal of Clinical Medicine myopia control contact lens choroidal thickness ERG retinal activity |
| title | Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens |
| title_full | Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens |
| title_fullStr | Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens |
| title_full_unstemmed | Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens |
| title_short | Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens |
| title_sort | changes in choroidal thickness and retinal activity with a myopia control contact lens |
| topic | myopia control contact lens choroidal thickness ERG retinal activity |
| url | https://www.mdpi.com/2077-0383/12/11/3618 |
| work_keys_str_mv | AT anaamorimdesousa changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens AT jaumepaune changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens AT sarasilvaleite changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens AT paulofernandes changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens AT josemanuelgozalezmeijome changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens AT antonioqueiros changesinchoroidalthicknessandretinalactivitywithamyopiacontrolcontactlens |