The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function. NRG-1/ErbB signaling is involved in a multitude of cardiac processes r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S20061 |
| _version_ | 1818261142781296640 |
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| author | Cassady E. Rupert Kareen L.K. Coulombe |
| author_facet | Cassady E. Rupert Kareen L.K. Coulombe |
| author_sort | Cassady E. Rupert |
| collection | DOAJ |
| description | Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function. NRG-1/ErbB signaling is involved in a multitude of cardiac processes ranging from myocardial and cardiac conduction system development to angiogenic support of cardiomyocytes, to cardioprotective effects upon injury. Numerous studies of NRG-1 employ a variety of platforms, including in vitro assays, animal models, and human clinical trials, with equally varying and, sometimes, contradictory outcomes. NRG-1 has the potential to be used as a therapeutic tool in stem cell therapies, tissue engineering applications, and clinical diagnostics and treatment. This review presents a concise summary of the growing body of literature to highlight the temporally persistent significance of NRG-1/ErbB signaling throughout development, homeostasis, and disease in the heart, specifically in cardiomyocytes. |
| first_indexed | 2024-12-12T18:42:32Z |
| format | Article |
| id | doaj.art-2af6451d70d14199aff22f9827db5422 |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-12T18:42:32Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-2af6451d70d14199aff22f9827db54222022-12-22T00:15:36ZengSAGE PublishingBiomarker Insights1177-27192015-01-0110s110.4137/BMI.S20061The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and DiseaseCassady E. Rupert0Kareen L.K. Coulombe1Center for Biomedical Engineering, School of Engineering.Department of Molecular Pharmacology, Physiology and Biotechnology, Division of Biology and Medicine, Brown University, Providence, RI, USA.Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function. NRG-1/ErbB signaling is involved in a multitude of cardiac processes ranging from myocardial and cardiac conduction system development to angiogenic support of cardiomyocytes, to cardioprotective effects upon injury. Numerous studies of NRG-1 employ a variety of platforms, including in vitro assays, animal models, and human clinical trials, with equally varying and, sometimes, contradictory outcomes. NRG-1 has the potential to be used as a therapeutic tool in stem cell therapies, tissue engineering applications, and clinical diagnostics and treatment. This review presents a concise summary of the growing body of literature to highlight the temporally persistent significance of NRG-1/ErbB signaling throughout development, homeostasis, and disease in the heart, specifically in cardiomyocytes.https://doi.org/10.4137/BMI.S20061 |
| spellingShingle | Cassady E. Rupert Kareen L.K. Coulombe The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease Biomarker Insights |
| title | The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease |
| title_full | The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease |
| title_fullStr | The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease |
| title_full_unstemmed | The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease |
| title_short | The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease |
| title_sort | roles of neuregulin 1 in cardiac development homeostasis and disease |
| url | https://doi.org/10.4137/BMI.S20061 |
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