From circuits to behavior: Amygdala dysfunction in fragile X syndrome
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early dev...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnint.2023.1128529/full |
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| author | Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Regina Sullivan Regina Sullivan Diego Restrepo Diego Restrepo Molly M. Huntsman Molly M. Huntsman Molly M. Huntsman |
| author_facet | Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Regina Sullivan Regina Sullivan Diego Restrepo Diego Restrepo Molly M. Huntsman Molly M. Huntsman Molly M. Huntsman |
| author_sort | Matthew N. Svalina |
| collection | DOAJ |
| description | Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early development of the brain. Thus, loss of the FMRP has well-known consequences for normal cellular and synaptic development leading to a variety of neuropsychiatric disorders including an increased prevalence of amygdala-based disorders. Despite our detailed understanding of the pathophysiology of FXS, the precise cellular and circuit-level underpinnings of amygdala-based disorders is incompletely understood. In this review, we discuss the development of the amygdala, the role of neuromodulation in the critical period plasticity, and recent advances in our understanding of how synaptic and circuit-level changes in the basolateral amygdala contribute to the behavioral manifestations seen in FXS. |
| first_indexed | 2024-04-10T05:12:25Z |
| format | Article |
| id | doaj.art-2af72f50d48e4f19a3518a0fea1f48b0 |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-04-10T05:12:25Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-2af72f50d48e4f19a3518a0fea1f48b02023-03-09T06:36:47ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452023-03-011710.3389/fnint.2023.11285291128529From circuits to behavior: Amygdala dysfunction in fragile X syndromeMatthew N. Svalina0Matthew N. Svalina1Matthew N. Svalina2Matthew N. Svalina3Regina Sullivan4Regina Sullivan5Diego Restrepo6Diego Restrepo7Molly M. Huntsman8Molly M. Huntsman9Molly M. Huntsman10Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesBrain Institute, Nathan Kline Institute, Orangeburg, NY, United StatesChild and Adolescent Psychiatry, Child Study Center, New York University School of Medicine, New York, NY, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesFragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early development of the brain. Thus, loss of the FMRP has well-known consequences for normal cellular and synaptic development leading to a variety of neuropsychiatric disorders including an increased prevalence of amygdala-based disorders. Despite our detailed understanding of the pathophysiology of FXS, the precise cellular and circuit-level underpinnings of amygdala-based disorders is incompletely understood. In this review, we discuss the development of the amygdala, the role of neuromodulation in the critical period plasticity, and recent advances in our understanding of how synaptic and circuit-level changes in the basolateral amygdala contribute to the behavioral manifestations seen in FXS.https://www.frontiersin.org/articles/10.3389/fnint.2023.1128529/fullcritical periodsynaptic plasticitybasolateral amygdalafragile X syndromedevelopmentE/I balance |
| spellingShingle | Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Matthew N. Svalina Regina Sullivan Regina Sullivan Diego Restrepo Diego Restrepo Molly M. Huntsman Molly M. Huntsman Molly M. Huntsman From circuits to behavior: Amygdala dysfunction in fragile X syndrome Frontiers in Integrative Neuroscience critical period synaptic plasticity basolateral amygdala fragile X syndrome development E/I balance |
| title | From circuits to behavior: Amygdala dysfunction in fragile X syndrome |
| title_full | From circuits to behavior: Amygdala dysfunction in fragile X syndrome |
| title_fullStr | From circuits to behavior: Amygdala dysfunction in fragile X syndrome |
| title_full_unstemmed | From circuits to behavior: Amygdala dysfunction in fragile X syndrome |
| title_short | From circuits to behavior: Amygdala dysfunction in fragile X syndrome |
| title_sort | from circuits to behavior amygdala dysfunction in fragile x syndrome |
| topic | critical period synaptic plasticity basolateral amygdala fragile X syndrome development E/I balance |
| url | https://www.frontiersin.org/articles/10.3389/fnint.2023.1128529/full |
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