From circuits to behavior: Amygdala dysfunction in fragile X syndrome

From circuits to behavior: Amygdala dysfunction in fragile X syndrome

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early dev...

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Bibliographic Details
Main Authors: Matthew N. Svalina, Regina Sullivan, Diego Restrepo, Molly M. Huntsman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Integrative Neuroscience
Subjects:
critical period
synaptic plasticity
basolateral amygdala
fragile X syndrome
development
E/I balance
Online Access:https://www.frontiersin.org/articles/10.3389/fnint.2023.1128529/full

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