Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean
Abstract Background It is known that standardized incidence rates of hip fracture vary among older people in Spain. So far, the results published on the validation of the FRAX® tool in Spain have suggested that the major osteoporotic fractures (MOFs) risk in our country is underestimated. These stud...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06670-w |
| _version_ | 1797779103031492608 |
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| author | Marta Zwart Rafael Azagra-Ledesma Marc Saez Amada Aguyé-Batista Miguel Angel Díaz-Herrera Salvador Tranche-Iparraguirre |
| author_facet | Marta Zwart Rafael Azagra-Ledesma Marc Saez Amada Aguyé-Batista Miguel Angel Díaz-Herrera Salvador Tranche-Iparraguirre |
| author_sort | Marta Zwart |
| collection | DOAJ |
| description | Abstract Background It is known that standardized incidence rates of hip fracture vary among older people in Spain. So far, the results published on the validation of the FRAX® tool in Spain have suggested that the major osteoporotic fractures (MOFs) risk in our country is underestimated. These studies have practically been based on Spanish cohorts evaluated in Catalonia, a higher hip fracture rate area. The purpose of this study is to analyse the ability of the FRAX® in a Spanish mid-fracture rate population. Methods Study design: Retrospective cohort study. Measures MOFs: hip, humerus, wrist, spine fractures. Risk of fracture assessed by calculating odds ratios (ORs). Predictive capacity of FRAX® according to the osteoporotic fractures observed between 2009 and 2018 (ObsFr) to predicted by FRAX® without densitometry in 2009 (PredFr) ratio. Results 285 participants (156 women, 54.7%) with a mean ± SD of 61.5 ± 14 years. Twenty-four people sustained 27 fractures (15 MOFs). Significant ORs were observed for an age ≥ 65 (2.92; 95% CI, 1.07–7.96), female sex (3.18; 95% CI, 1.24–8.16), rheumatoid arthritis (0.62; 95% CI, 2.03–55.55), proton pump (2.71; 95% CI, 1.20–6.09) and serotonin reuptake (2.51; 95% CI, 1.02–6.16) inhibitors. The ObsFr/PredFr ratio in women were 1.12 (95% CI, 0.95–1.29) for MOFs and 0.47 (95% CI, 0-0.94) for hip fractures. Men had a ratio of 0.57 (95% CI, 0.01–1.14) for MOF, no hip fractures were observed. The ratios for the overall group were 1.29 (95% CI, 1.12–1.48) for MOFs and 0.70 (95% CI, 0.22–1.17) for hip fractures. Conclusions FRAX® accurately predicted MOFs in women population with a hip fracture incidence rate close to the national mean compared to previous studies conducted in higher incidence regions in Spain. |
| first_indexed | 2024-03-12T23:26:54Z |
| format | Article |
| id | doaj.art-2af84452e5784051be5bc874d2d95005 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-12T23:26:54Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-2af84452e5784051be5bc874d2d950052023-07-16T11:03:41ZengBMCBMC Musculoskeletal Disorders1471-24742023-07-012411710.1186/s12891-023-06670-wPredictive capacity of FRAX in a spanish region with a hip fracture rate close to the national meanMarta Zwart0Rafael Azagra-Ledesma1Marc Saez2Amada Aguyé-Batista3Miguel Angel Díaz-Herrera4Salvador Tranche-Iparraguirre5Medicina de Familia. Centro de Atención Primaria Can Gibert del Pla, Institut Català de la Salut (ICS)Medicina de Familia. Centro de Atención Primaria Badía del Vallés, Institut Català de la Salut (ICS). C/ Bètica s/nBioestadística. Universitat de Girona (UdG), C/de la Universitat de Girona 10GROICAP. Unitat Suport a la Recerca (USR) Girona-IDIAP Jordi GolGROICAP. Unitat Suport a la Recerca (USR) Girona-IDIAP Jordi GolComisión de Docencia. Hospital Universitario General de Catalunya-Grupo QuironsaludAbstract Background It is known that standardized incidence rates of hip fracture vary among older people in Spain. So far, the results published on the validation of the FRAX® tool in Spain have suggested that the major osteoporotic fractures (MOFs) risk in our country is underestimated. These studies have practically been based on Spanish cohorts evaluated in Catalonia, a higher hip fracture rate area. The purpose of this study is to analyse the ability of the FRAX® in a Spanish mid-fracture rate population. Methods Study design: Retrospective cohort study. Measures MOFs: hip, humerus, wrist, spine fractures. Risk of fracture assessed by calculating odds ratios (ORs). Predictive capacity of FRAX® according to the osteoporotic fractures observed between 2009 and 2018 (ObsFr) to predicted by FRAX® without densitometry in 2009 (PredFr) ratio. Results 285 participants (156 women, 54.7%) with a mean ± SD of 61.5 ± 14 years. Twenty-four people sustained 27 fractures (15 MOFs). Significant ORs were observed for an age ≥ 65 (2.92; 95% CI, 1.07–7.96), female sex (3.18; 95% CI, 1.24–8.16), rheumatoid arthritis (0.62; 95% CI, 2.03–55.55), proton pump (2.71; 95% CI, 1.20–6.09) and serotonin reuptake (2.51; 95% CI, 1.02–6.16) inhibitors. The ObsFr/PredFr ratio in women were 1.12 (95% CI, 0.95–1.29) for MOFs and 0.47 (95% CI, 0-0.94) for hip fractures. Men had a ratio of 0.57 (95% CI, 0.01–1.14) for MOF, no hip fractures were observed. The ratios for the overall group were 1.29 (95% CI, 1.12–1.48) for MOFs and 0.70 (95% CI, 0.22–1.17) for hip fractures. Conclusions FRAX® accurately predicted MOFs in women population with a hip fracture incidence rate close to the national mean compared to previous studies conducted in higher incidence regions in Spain.https://doi.org/10.1186/s12891-023-06670-wFRAX®Primary careOsteoporotic fracture riskOsteoporotic fracture |
| spellingShingle | Marta Zwart Rafael Azagra-Ledesma Marc Saez Amada Aguyé-Batista Miguel Angel Díaz-Herrera Salvador Tranche-Iparraguirre Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean BMC Musculoskeletal Disorders FRAX® Primary care Osteoporotic fracture risk Osteoporotic fracture |
| title | Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean |
| title_full | Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean |
| title_fullStr | Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean |
| title_full_unstemmed | Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean |
| title_short | Predictive capacity of FRAX in a spanish region with a hip fracture rate close to the national mean |
| title_sort | predictive capacity of frax in a spanish region with a hip fracture rate close to the national mean |
| topic | FRAX® Primary care Osteoporotic fracture risk Osteoporotic fracture |
| url | https://doi.org/10.1186/s12891-023-06670-w |
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