Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions
Posterior cingulate cortex (area 23, A23) in human and monkeys is a critical component of the default mode network and is involved in many diseases such as Alzheimer’s disease, autism, depression, attention deficit hyperactivity disorder and schizophrenia. However, A23 has not yet identified in rode...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1194299/full |
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| author | Xiao-Jun Xiang Xiao-Jun Xiang Sheng-Qiang Chen Xue-Qin Zhang Chang-Hui Chen Shun-Yu Zhang Hui-Ru Cai Song-Lin Ding Song-Lin Ding |
| author_facet | Xiao-Jun Xiang Xiao-Jun Xiang Sheng-Qiang Chen Xue-Qin Zhang Chang-Hui Chen Shun-Yu Zhang Hui-Ru Cai Song-Lin Ding Song-Lin Ding |
| author_sort | Xiao-Jun Xiang |
| collection | DOAJ |
| description | Posterior cingulate cortex (area 23, A23) in human and monkeys is a critical component of the default mode network and is involved in many diseases such as Alzheimer’s disease, autism, depression, attention deficit hyperactivity disorder and schizophrenia. However, A23 has not yet identified in rodents, and this makes modeling related circuits and diseases in rodents very difficult. Using a comparative approach, molecular markers and unique connectional patterns this study has uncovered the location and extent of possible rodent equivalent (A23~) of the primate A23. A23 ~ but not adjoining areas in the rodents displays strong reciprocal connections with anteromedial thalamic nucleus. Rodent A23 ~ reciprocally connects with the medial pulvinar and claustrum as well as with anterior cingulate, granular retrosplenial, medial orbitofrontal, postrhinal, and visual and auditory association cortices. Rodent A23 ~ projects to dorsal striatum, ventral lateral geniculate nucleus, zona incerta, pretectal nucleus, superior colliculus, periaqueductal gray, and brainstem. All these findings support the versatility of A23 in the integration and modulation of multimodal sensory information underlying spatial processing, episodic memory, self-reflection, attention, value assessment and many adaptive behaviors. Additionally, this study also suggests that the rodents could be used to model monkey and human A23 in future structural, functional, pathological, and neuromodulation studies. |
| first_indexed | 2024-03-13T05:56:40Z |
| format | Article |
| id | doaj.art-2af87e1840ad41b6a08b6161016498a1 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T05:56:40Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2af87e1840ad41b6a08b6161016498a12023-06-13T04:22:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11942991194299Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regionsXiao-Jun Xiang0Xiao-Jun Xiang1Sheng-Qiang Chen2Xue-Qin Zhang3Chang-Hui Chen4Shun-Yu Zhang5Hui-Ru Cai6Song-Lin Ding7Song-Lin Ding8Department of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaDepartment of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaDepartment of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaDepartment of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaAllen Institute for Brain Science, Seattle, WA, United StatesPosterior cingulate cortex (area 23, A23) in human and monkeys is a critical component of the default mode network and is involved in many diseases such as Alzheimer’s disease, autism, depression, attention deficit hyperactivity disorder and schizophrenia. However, A23 has not yet identified in rodents, and this makes modeling related circuits and diseases in rodents very difficult. Using a comparative approach, molecular markers and unique connectional patterns this study has uncovered the location and extent of possible rodent equivalent (A23~) of the primate A23. A23 ~ but not adjoining areas in the rodents displays strong reciprocal connections with anteromedial thalamic nucleus. Rodent A23 ~ reciprocally connects with the medial pulvinar and claustrum as well as with anterior cingulate, granular retrosplenial, medial orbitofrontal, postrhinal, and visual and auditory association cortices. Rodent A23 ~ projects to dorsal striatum, ventral lateral geniculate nucleus, zona incerta, pretectal nucleus, superior colliculus, periaqueductal gray, and brainstem. All these findings support the versatility of A23 in the integration and modulation of multimodal sensory information underlying spatial processing, episodic memory, self-reflection, attention, value assessment and many adaptive behaviors. Additionally, this study also suggests that the rodents could be used to model monkey and human A23 in future structural, functional, pathological, and neuromodulation studies.https://www.frontiersin.org/articles/10.3389/fnins.2023.1194299/fullcingulate cortexretrosplenial cortexorbital frontal cortexpostrhinal cortexclaustrumanterior thalamic nucleus |
| spellingShingle | Xiao-Jun Xiang Xiao-Jun Xiang Sheng-Qiang Chen Xue-Qin Zhang Chang-Hui Chen Shun-Yu Zhang Hui-Ru Cai Song-Lin Ding Song-Lin Ding Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions Frontiers in Neuroscience cingulate cortex retrosplenial cortex orbital frontal cortex postrhinal cortex claustrum anterior thalamic nucleus |
| title | Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions |
| title_full | Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions |
| title_fullStr | Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions |
| title_full_unstemmed | Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions |
| title_short | Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions |
| title_sort | possible rodent equivalent of the posterior cingulate cortex area 23 interconnects with multimodal cortical and subcortical regions |
| topic | cingulate cortex retrosplenial cortex orbital frontal cortex postrhinal cortex claustrum anterior thalamic nucleus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1194299/full |
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