Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the respons...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2000-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100013 |
| _version_ | 1818930197420834816 |
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| author | Silveira P.P. Xavier M.H. Souza F.H. Manoli L.P. Rosat R.M. Ferreira M.B.C. Dalmaz C. |
| author_facet | Silveira P.P. Xavier M.H. Souza F.H. Manoli L.P. Rosat R.M. Ferreira M.B.C. Dalmaz C. |
| author_sort | Silveira P.P. |
| collection | DOAJ |
| description | Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect. |
| first_indexed | 2024-12-20T03:56:52Z |
| format | Article |
| id | doaj.art-2af91136c97d4af79ebe1a0eff31529f |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-12-20T03:56:52Z |
| publishDate | 2000-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-2af91136c97d4af79ebe1a0eff31529f2022-12-21T19:54:18ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73102000-01-01331113431350Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in ratsSilveira P.P.Xavier M.H.Souza F.H.Manoli L.P.Rosat R.M.Ferreira M.B.C.Dalmaz C.Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100013feeding behaviorchronic stressbenzodiazepinesmidazolamsweet tasterats |
| spellingShingle | Silveira P.P. Xavier M.H. Souza F.H. Manoli L.P. Rosat R.M. Ferreira M.B.C. Dalmaz C. Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats Brazilian Journal of Medical and Biological Research feeding behavior chronic stress benzodiazepines midazolam sweet taste rats |
| title | Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| title_full | Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| title_fullStr | Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| title_full_unstemmed | Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| title_short | Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| title_sort | interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
| topic | feeding behavior chronic stress benzodiazepines midazolam sweet taste rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100013 |
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