Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration

Abstract Background Cell transplantation has been demonstrated as a promising approach in tissue regeneration. However, the reactive oxygen species (ROS) accumulation and inflammation condition establish a harsh microenvironment in degenerated tissue, which makes the transplanted cells difficult to...

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Bibliographic Details
Main Authors: Yingchuang Tang, Kai Zhang, Hongyou Zhou, Chenchen Zhang, Zixiang Liu, Hao Chen, Hanwen Li, Kangwu Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Nanobiotechnology
Subjects:
Intervertebral disc degeneration
Nucleus pulposus cells transplantation
Hydrogel microspheres
Magnesium ion
Online Access:https://doi.org/10.1186/s12951-023-02226-1

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