Homemade: building the structure of the neurogenic niche
Neural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their function and enables neurogenesis. The niche is made of a diversity of cell types, including neurons, glia and the vasculature, which are able to signal to and are structurally organise...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1275963/full |
| _version_ | 1797434820387667968 |
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| author | Ghanim Fajish Valamparamban Pauline Spéder |
| author_facet | Ghanim Fajish Valamparamban Pauline Spéder |
| author_sort | Ghanim Fajish Valamparamban |
| collection | DOAJ |
| description | Neural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their function and enables neurogenesis. The niche is made of a diversity of cell types, including neurons, glia and the vasculature, which are able to signal to and are structurally organised around neural stem/progenitor cells. While the focus has been on how individual cell types signal to and influence the behaviour of neural stem/progenitor cells, very little is actually known on how the niche is assembled during development from multiple cellular origins, and on the role of the resulting topology on these cells. This review proposes to draw a state-of-the art picture of this emerging field of research, with the aim to expose our knowledge on niche architecture and formation from different animal models (mouse, zebrafish and fruit fly). We will span its multiple aspects, from the existence and importance of local, adhesive interactions to the potential emergence of larger-scale topological properties through the careful assembly of diverse cellular and acellular components. |
| first_indexed | 2024-03-09T10:38:24Z |
| format | Article |
| id | doaj.art-2af9742717954959858bf2cf21033aa5 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-09T10:38:24Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2af9742717954959858bf2cf21033aa52023-12-01T19:03:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-12-011110.3389/fcell.2023.12759631275963Homemade: building the structure of the neurogenic nicheGhanim Fajish ValamparambanPauline SpéderNeural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their function and enables neurogenesis. The niche is made of a diversity of cell types, including neurons, glia and the vasculature, which are able to signal to and are structurally organised around neural stem/progenitor cells. While the focus has been on how individual cell types signal to and influence the behaviour of neural stem/progenitor cells, very little is actually known on how the niche is assembled during development from multiple cellular origins, and on the role of the resulting topology on these cells. This review proposes to draw a state-of-the art picture of this emerging field of research, with the aim to expose our knowledge on niche architecture and formation from different animal models (mouse, zebrafish and fruit fly). We will span its multiple aspects, from the existence and importance of local, adhesive interactions to the potential emergence of larger-scale topological properties through the careful assembly of diverse cellular and acellular components.https://www.frontiersin.org/articles/10.3389/fcell.2023.1275963/fullneural stem cell (NSC)nichearchitecturedevelopmentmousezebrafish |
| spellingShingle | Ghanim Fajish Valamparamban Pauline Spéder Homemade: building the structure of the neurogenic niche Frontiers in Cell and Developmental Biology neural stem cell (NSC) niche architecture development mouse zebrafish |
| title | Homemade: building the structure of the neurogenic niche |
| title_full | Homemade: building the structure of the neurogenic niche |
| title_fullStr | Homemade: building the structure of the neurogenic niche |
| title_full_unstemmed | Homemade: building the structure of the neurogenic niche |
| title_short | Homemade: building the structure of the neurogenic niche |
| title_sort | homemade building the structure of the neurogenic niche |
| topic | neural stem cell (NSC) niche architecture development mouse zebrafish |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1275963/full |
| work_keys_str_mv | AT ghanimfajishvalamparamban homemadebuildingthestructureoftheneurogenicniche AT paulinespeder homemadebuildingthestructureoftheneurogenicniche |