A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019?
In March 2020, the first pandemic caused by a coronavirus was declared by the World Health Organization. Italy was one of the first and most severely affected countries, particularly the northern part of the country. The latest evidence suggests that the virus could have been circulating, at least i...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2047582 |
| _version_ | 1827806457931759616 |
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| author | Claudia Maria Trombetta Serena Marchi Simonetta Viviani Alessandro Manenti Elisa Casa Francesca Dapporto Edmond J. Remarque Valentina Bollati Ilaria Manini Giacomo Lazzeri Emanuele Montomoli |
| author_facet | Claudia Maria Trombetta Serena Marchi Simonetta Viviani Alessandro Manenti Elisa Casa Francesca Dapporto Edmond J. Remarque Valentina Bollati Ilaria Manini Giacomo Lazzeri Emanuele Montomoli |
| author_sort | Claudia Maria Trombetta |
| collection | DOAJ |
| description | In March 2020, the first pandemic caused by a coronavirus was declared by the World Health Organization. Italy was one of the first and most severely affected countries, particularly the northern part of the country. The latest evidence suggests that the virus could have been circulating, at least in Italy, before the first autochthonous SARS-COV-2 case was detected in February 2020. The present study aimed to investigate the presence of antibodies against SARS-CoV-2 in human serum samples collected in the last months of 2019 (September–December) in the Apulia region, Southern Italy. Eight of 455 samples tested proved positive on in-house receptor-binding-domain-based ELISA. Given the month of collection of the positive samples, these findings may indicate early circulation of SARS-CoV-2 in Apulia region in the autumn of 2019. However, it cannot be completely ruled out that the observed sero-reactivity could be an unknown antigen specificity in another virus to which subjects were exposed containing an epitope adventitiously cross-reactive with an epitope of SARS-CoV-2. |
| first_indexed | 2024-03-11T21:41:26Z |
| format | Article |
| id | doaj.art-2afc0bde022b4916af4e61b239e5e9ef |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:41:26Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-2afc0bde022b4916af4e61b239e5e9ef2023-09-26T13:19:05ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-11-0118510.1080/21645515.2022.20475822047582A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019?Claudia Maria Trombetta0Serena Marchi1Simonetta Viviani2Alessandro Manenti3Elisa Casa4Francesca Dapporto5Edmond J. Remarque6Valentina Bollati7Ilaria Manini8Giacomo Lazzeri9Emanuele Montomoli10University of SienaUniversity of SienaUniversity of SienaVisMederi srlVisMederi Research srlVisMederi Research srlBiomedical Primate Research CentreUniversity of MilanUniversity of SienaUniversity of SienaUniversity of SienaIn March 2020, the first pandemic caused by a coronavirus was declared by the World Health Organization. Italy was one of the first and most severely affected countries, particularly the northern part of the country. The latest evidence suggests that the virus could have been circulating, at least in Italy, before the first autochthonous SARS-COV-2 case was detected in February 2020. The present study aimed to investigate the presence of antibodies against SARS-CoV-2 in human serum samples collected in the last months of 2019 (September–December) in the Apulia region, Southern Italy. Eight of 455 samples tested proved positive on in-house receptor-binding-domain-based ELISA. Given the month of collection of the positive samples, these findings may indicate early circulation of SARS-CoV-2 in Apulia region in the autumn of 2019. However, it cannot be completely ruled out that the observed sero-reactivity could be an unknown antigen specificity in another virus to which subjects were exposed containing an epitope adventitiously cross-reactive with an epitope of SARS-CoV-2.http://dx.doi.org/10.1080/21645515.2022.2047582sars-cov-2antibodies2019italy |
| spellingShingle | Claudia Maria Trombetta Serena Marchi Simonetta Viviani Alessandro Manenti Elisa Casa Francesca Dapporto Edmond J. Remarque Valentina Bollati Ilaria Manini Giacomo Lazzeri Emanuele Montomoli A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? Human Vaccines & Immunotherapeutics sars-cov-2 antibodies 2019 italy |
| title | A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? |
| title_full | A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? |
| title_fullStr | A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? |
| title_full_unstemmed | A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? |
| title_short | A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019? |
| title_sort | serological investigation in southern italy was sars cov 2 circulating in late 2019 |
| topic | sars-cov-2 antibodies 2019 italy |
| url | http://dx.doi.org/10.1080/21645515.2022.2047582 |
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