TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS

TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal, complex neurodegenerative disorder that causes selective degeneration of motor neurons. ALS patients exhibit symptoms consistent with altered cellular energetics such as hypermetabolism, weight loss, dyslipidemia, insulin resistance, and altered glucos...

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Bibliographic Details
Main Authors: Suvithanandhini Loganathan, Bryce A. Wilson, Sara B. Carey, Ernesto Manzo, Archi Joardar, Berrak Ugur, Daniela C. Zarnescu
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Metabolites
Subjects:
Amyotrophic lateral sclerosis (ALS)
metabolic alterations
Tricarboxylic acid (TCA) cycle
glutamine
pyruvate
dopamine
Online Access:https://www.mdpi.com/2218-1989/12/2/101

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https://www.mdpi.com/2218-1989/12/2/101

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