Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients
Objective: H2 blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H2 blockers (H2 group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2012-07-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/341873 |
| _version_ | 1828231107945955328 |
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| author | Shiro Fujii Hitoshi Tanimukai Yujiro Kashiwagi |
| author_facet | Shiro Fujii Hitoshi Tanimukai Yujiro Kashiwagi |
| author_sort | Shiro Fujii |
| collection | DOAJ |
| description | Objective: H2 blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H2 blockers (H2 group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment of esophageal cancer. Method: The incidence and severity of delirium were retrospectively compared in patients of the H2 group (30 cases; age, 65.2 ± 8.1 years) and the PPI group (30 cases; 65.2 ± 6.5 years). The diagnosis of delirium was based on the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision. Delirium severity was rated on the Delirium Rating Scale (DRS). Results: The incidence of delirium was significantly lower in the PPI group than in the H2 group (p = 0.047). In the 11 patients from the H2 group who developed delirium, discontinuation of H2 blockers resulted in a significant reduction in the DRS score (p = 0.009). In three patients for whom H2 blockers were discontinued, DRS scores decreased by 50% or more three days after discontinuation compared to the prediscontinuation score. Conclusions: These results suggested that switching antiulcer drugs from H2 blockers to PPIs reduced delirium and thus provided an appropriate coping method for drug-induced delirium from antiulcer drugs. |
| first_indexed | 2024-04-12T18:58:23Z |
| format | Article |
| id | doaj.art-2b012d20ed0e474f9032358c0ff29919 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T18:58:23Z |
| publishDate | 2012-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-2b012d20ed0e474f9032358c0ff299192022-12-22T03:20:14ZengKarger PublishersCase Reports in Oncology1662-65752012-07-015240941210.1159/000341873341873Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer PatientsShiro FujiiHitoshi TanimukaiYujiro KashiwagiObjective: H2 blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H2 blockers (H2 group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment of esophageal cancer. Method: The incidence and severity of delirium were retrospectively compared in patients of the H2 group (30 cases; age, 65.2 ± 8.1 years) and the PPI group (30 cases; 65.2 ± 6.5 years). The diagnosis of delirium was based on the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision. Delirium severity was rated on the Delirium Rating Scale (DRS). Results: The incidence of delirium was significantly lower in the PPI group than in the H2 group (p = 0.047). In the 11 patients from the H2 group who developed delirium, discontinuation of H2 blockers resulted in a significant reduction in the DRS score (p = 0.009). In three patients for whom H2 blockers were discontinued, DRS scores decreased by 50% or more three days after discontinuation compared to the prediscontinuation score. Conclusions: These results suggested that switching antiulcer drugs from H2 blockers to PPIs reduced delirium and thus provided an appropriate coping method for drug-induced delirium from antiulcer drugs.http://www.karger.com/Article/FullText/341873DeliriumH2 blockersProton pump inhibitorsSwitchingPrevention |
| spellingShingle | Shiro Fujii Hitoshi Tanimukai Yujiro Kashiwagi Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients Case Reports in Oncology Delirium H2 blockers Proton pump inhibitors Switching Prevention |
| title | Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients |
| title_full | Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients |
| title_fullStr | Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients |
| title_full_unstemmed | Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients |
| title_short | Comparison and Analysis of Delirium Induced by Histamine H2 Receptor Antagonists and Proton Pump Inhibitors in Cancer Patients |
| title_sort | comparison and analysis of delirium induced by histamine h2 receptor antagonists and proton pump inhibitors in cancer patients |
| topic | Delirium H2 blockers Proton pump inhibitors Switching Prevention |
| url | http://www.karger.com/Article/FullText/341873 |
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