Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing
Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection. It is a rapidly expanding field of cancer research. Epigenetics is the heritabl...
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| Format: | Article |
| Language: | English |
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University of Sistan and Baluchestan
2022-02-01
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| Series: | Journal of Epigenetics |
| Subjects: | |
| Online Access: | https://jep.usb.ac.ir/article_7106_55c8a41aeae8516e780f12ac935cb7f4.pdf |
| _version_ | 1797824892942417920 |
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| author | Samina Gul Tang Wenru |
| author_facet | Samina Gul Tang Wenru |
| author_sort | Samina Gul |
| collection | DOAJ |
| description | Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection. It is a rapidly expanding field of cancer research. Epigenetics is the heritable process that effects the gene expression without alteration in DNA sequences. Epigenetics includes three systems DNA methylation, histone modification, Non-coding RNA associated silencing gene and chromatin changes. Major epigenetics modifications include DNA methylation patterns that are modified in the cancer cell and used to distinguish a cancer cell from normal and strongly involved in the physiological control of genome expression. Cancer results from an aberration in genomic DNA include hypo-methylation and hyper-methylation of DNA. Hyper-methylation exhibit the silencing of Tumor suppressor genes. Hypo-methylation activate transcription of proto-oncogenes, cancer cell metastasis and genomic instability. Due to emergence of powerful technologies the detection of DNA methylation accelerated cancer research. DNA methyltransferases DNMT1 and DNMT3B catalyzed DNA methylation. DNA methylation associated with loss of gene expression. Different DNA Methylation biomarkers associated with different cancer types. This review highlights different DNA methylation biomarkers in different types of cancer which are helpful for diagnosis, prognosis and drug designing for curing different types of cancer. |
| first_indexed | 2024-03-13T10:46:03Z |
| format | Article |
| id | doaj.art-2b0531630aee432aa4669ae1b50b555b |
| institution | Directory Open Access Journal |
| issn | 2676-4350 |
| language | English |
| last_indexed | 2024-03-13T10:46:03Z |
| publishDate | 2022-02-01 |
| publisher | University of Sistan and Baluchestan |
| record_format | Article |
| series | Journal of Epigenetics |
| spelling | doaj.art-2b0531630aee432aa4669ae1b50b555b2023-05-17T18:59:14ZengUniversity of Sistan and BaluchestanJournal of Epigenetics2676-43502022-02-0131354210.22111/jep.2022.40064.10337106Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug DesigningSamina Gul0Tang Wenru1Faculty of medicine lab of molecular genetics of aging and tumor kunming university of science and technology chinaLab of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming university of science and technology chinaRecently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection. It is a rapidly expanding field of cancer research. Epigenetics is the heritable process that effects the gene expression without alteration in DNA sequences. Epigenetics includes three systems DNA methylation, histone modification, Non-coding RNA associated silencing gene and chromatin changes. Major epigenetics modifications include DNA methylation patterns that are modified in the cancer cell and used to distinguish a cancer cell from normal and strongly involved in the physiological control of genome expression. Cancer results from an aberration in genomic DNA include hypo-methylation and hyper-methylation of DNA. Hyper-methylation exhibit the silencing of Tumor suppressor genes. Hypo-methylation activate transcription of proto-oncogenes, cancer cell metastasis and genomic instability. Due to emergence of powerful technologies the detection of DNA methylation accelerated cancer research. DNA methyltransferases DNMT1 and DNMT3B catalyzed DNA methylation. DNA methylation associated with loss of gene expression. Different DNA Methylation biomarkers associated with different cancer types. This review highlights different DNA methylation biomarkers in different types of cancer which are helpful for diagnosis, prognosis and drug designing for curing different types of cancer.https://jep.usb.ac.ir/article_7106_55c8a41aeae8516e780f12ac935cb7f4.pdfdna methylationepigenetics mechanismhypo-methylationhyper-methylationbiomarkers in different cancer types |
| spellingShingle | Samina Gul Tang Wenru Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing Journal of Epigenetics dna methylation epigenetics mechanism hypo-methylation hyper-methylation biomarkers in different cancer types |
| title | Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing |
| title_full | Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing |
| title_fullStr | Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing |
| title_full_unstemmed | Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing |
| title_short | Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing |
| title_sort | highlight dna methylation biomarkers in different cancer type for drug designing |
| topic | dna methylation epigenetics mechanism hypo-methylation hyper-methylation biomarkers in different cancer types |
| url | https://jep.usb.ac.ir/article_7106_55c8a41aeae8516e780f12ac935cb7f4.pdf |
| work_keys_str_mv | AT saminagul highlightdnamethylationbiomarkersindifferentcancertypefordrugdesigning AT tangwenru highlightdnamethylationbiomarkersindifferentcancertypefordrugdesigning |