Use-case scenarios for an anti-Cryptosporidium therapeutic.
Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its recent "emergence" is largely the result of discoveries made through ma...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0009057 |
| _version_ | 1818581667115171840 |
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| author | Paul G Ashigbie Susan Shepherd Kevin L Steiner Beatrice Amadi Natasha Aziz Ujjini H Manjunatha Jonathan M Spector Thierry T Diagana Paul Kelly |
| author_facet | Paul G Ashigbie Susan Shepherd Kevin L Steiner Beatrice Amadi Natasha Aziz Ujjini H Manjunatha Jonathan M Spector Thierry T Diagana Paul Kelly |
| author_sort | Paul G Ashigbie |
| collection | DOAJ |
| description | Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its recent "emergence" is largely the result of discoveries made through major epidemiologic studies in the past decade. There is no vaccine, and the only approved medicine, nitazoxanide, has been shown to have efficacy limitations in several patient groups known to be at elevated risk of disease. In order to help frontline health workers, policymakers, and other stakeholders translate our current understanding of cryptosporidiosis into actionable guidance to address the disease, we sought to assess salient issues relating to clinical management of cryptosporidiosis drawing from a review of the literature and our own field-based practice. This exercise is meant to help inform health system strategies for improving access to current treatments, to highlight recent achievements and outstanding knowledge and clinical practice gaps, and to help guide research activities for new anti-Cryptosporidium therapies. |
| first_indexed | 2024-12-16T07:37:08Z |
| format | Article |
| id | doaj.art-2b0571b14ff849bb96c349c92fc27a13 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-16T07:37:08Z |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-2b0571b14ff849bb96c349c92fc27a132022-12-21T22:39:10ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-03-01153e000905710.1371/journal.pntd.0009057Use-case scenarios for an anti-Cryptosporidium therapeutic.Paul G AshigbieSusan ShepherdKevin L SteinerBeatrice AmadiNatasha AzizUjjini H ManjunathaJonathan M SpectorThierry T DiaganaPaul KellyCryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its recent "emergence" is largely the result of discoveries made through major epidemiologic studies in the past decade. There is no vaccine, and the only approved medicine, nitazoxanide, has been shown to have efficacy limitations in several patient groups known to be at elevated risk of disease. In order to help frontline health workers, policymakers, and other stakeholders translate our current understanding of cryptosporidiosis into actionable guidance to address the disease, we sought to assess salient issues relating to clinical management of cryptosporidiosis drawing from a review of the literature and our own field-based practice. This exercise is meant to help inform health system strategies for improving access to current treatments, to highlight recent achievements and outstanding knowledge and clinical practice gaps, and to help guide research activities for new anti-Cryptosporidium therapies.https://doi.org/10.1371/journal.pntd.0009057 |
| spellingShingle | Paul G Ashigbie Susan Shepherd Kevin L Steiner Beatrice Amadi Natasha Aziz Ujjini H Manjunatha Jonathan M Spector Thierry T Diagana Paul Kelly Use-case scenarios for an anti-Cryptosporidium therapeutic. PLoS Neglected Tropical Diseases |
| title | Use-case scenarios for an anti-Cryptosporidium therapeutic. |
| title_full | Use-case scenarios for an anti-Cryptosporidium therapeutic. |
| title_fullStr | Use-case scenarios for an anti-Cryptosporidium therapeutic. |
| title_full_unstemmed | Use-case scenarios for an anti-Cryptosporidium therapeutic. |
| title_short | Use-case scenarios for an anti-Cryptosporidium therapeutic. |
| title_sort | use case scenarios for an anti cryptosporidium therapeutic |
| url | https://doi.org/10.1371/journal.pntd.0009057 |
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