Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus
Ultrasonographic parameters such as the common carotid artery (CCA) pulsatility index (PI) and CCA intima-media thickness (IMT) have been associated with an increased mortality and risk of recurrent stroke, respectively. We hypothesized that these ultrasonographic parameters may be useful for monito...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/1/246 |
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| author | Olivier Bill Michael V. Mazya Patrik Michel Tiago Prazeres Moreira Dimitris Lambrou Ivo A. Meyer Lorenz Hirt |
| author_facet | Olivier Bill Michael V. Mazya Patrik Michel Tiago Prazeres Moreira Dimitris Lambrou Ivo A. Meyer Lorenz Hirt |
| author_sort | Olivier Bill |
| collection | DOAJ |
| description | Ultrasonographic parameters such as the common carotid artery (CCA) pulsatility index (PI) and CCA intima-media thickness (IMT) have been associated with an increased mortality and risk of recurrent stroke, respectively. We hypothesized that these ultrasonographic parameters may be useful for monitoring diabetic patients after an acute stroke. We analysed retrospective data of consecutive acute ischaemic stroke patients from the ASTRAL registry who underwent pre-cerebral ultrasonographic evaluation within 7 days of symptom onset. We compared clinical, demographic, radiological and ultrasonographic parameters in diabetic versus non-diabetic patients (univariable and multivariable analyses) and the association of these parameters with CCA PI and CCA IMT. We analysed 1507 carotid duplex ultrasound examinations from patients with a median age of 74 years. Cardiovascular co-morbidities, including hypertension, hypercholesterolemia, obstructive sleep apnoea syndrome, higher body-mass index (BMI) and peripheral artery disease, were associated with diabetes mellitus (DM). Diabetics were more often under antiplatelet therapy and had atrial fibrillation at admission. Diabetic patients showed an increased CCA PI and IMT in line with more atherosclerotic changes on acute CTA compared to non-diabetic patients. Taking IMT as the dependent variable in a second analysis, DM, higher age, hypertension, smoking and CCA PI were associated with higher IMT. Taking CCA PI as the dependent variable in a third analysis, DM, higher age and higher NIHSS at admission were associated with higher CCA PI values. Increased IMT was also associated with higher PI. We show that CCA PI and IMT are higher in diabetic patients in the first week after an initial stroke. |
| first_indexed | 2024-03-11T09:56:41Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:56:41Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2b064f935e2c4d0b8fcc0857161324a22023-11-16T15:43:28ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-0112124610.3390/jcm12010246Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes MellitusOlivier Bill0Michael V. Mazya1Patrik Michel2Tiago Prazeres Moreira3Dimitris Lambrou4Ivo A. Meyer5Lorenz Hirt6Department of Neurology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Neurology, Karolinska University Hospital, 171 77 Stockholm, SwedenDepartment of Neurology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Neurology, Karolinska University Hospital, 171 77 Stockholm, SwedenDepartment of Neurology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Neurology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Neurology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, SwitzerlandUltrasonographic parameters such as the common carotid artery (CCA) pulsatility index (PI) and CCA intima-media thickness (IMT) have been associated with an increased mortality and risk of recurrent stroke, respectively. We hypothesized that these ultrasonographic parameters may be useful for monitoring diabetic patients after an acute stroke. We analysed retrospective data of consecutive acute ischaemic stroke patients from the ASTRAL registry who underwent pre-cerebral ultrasonographic evaluation within 7 days of symptom onset. We compared clinical, demographic, radiological and ultrasonographic parameters in diabetic versus non-diabetic patients (univariable and multivariable analyses) and the association of these parameters with CCA PI and CCA IMT. We analysed 1507 carotid duplex ultrasound examinations from patients with a median age of 74 years. Cardiovascular co-morbidities, including hypertension, hypercholesterolemia, obstructive sleep apnoea syndrome, higher body-mass index (BMI) and peripheral artery disease, were associated with diabetes mellitus (DM). Diabetics were more often under antiplatelet therapy and had atrial fibrillation at admission. Diabetic patients showed an increased CCA PI and IMT in line with more atherosclerotic changes on acute CTA compared to non-diabetic patients. Taking IMT as the dependent variable in a second analysis, DM, higher age, hypertension, smoking and CCA PI were associated with higher IMT. Taking CCA PI as the dependent variable in a third analysis, DM, higher age and higher NIHSS at admission were associated with higher CCA PI values. Increased IMT was also associated with higher PI. We show that CCA PI and IMT are higher in diabetic patients in the first week after an initial stroke.https://www.mdpi.com/2077-0383/12/1/246strokediabetes mellitusduplex sonographypulsatility indexintima-media thicknessacute ischemic stroke |
| spellingShingle | Olivier Bill Michael V. Mazya Patrik Michel Tiago Prazeres Moreira Dimitris Lambrou Ivo A. Meyer Lorenz Hirt Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus Journal of Clinical Medicine stroke diabetes mellitus duplex sonography pulsatility index intima-media thickness acute ischemic stroke |
| title | Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus |
| title_full | Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus |
| title_fullStr | Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus |
| title_full_unstemmed | Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus |
| title_short | Intima-Media Thickness and Pulsatility Index of Common Carotid Arteries in Acute Ischaemic Stroke Patients with Diabetes Mellitus |
| title_sort | intima media thickness and pulsatility index of common carotid arteries in acute ischaemic stroke patients with diabetes mellitus |
| topic | stroke diabetes mellitus duplex sonography pulsatility index intima-media thickness acute ischemic stroke |
| url | https://www.mdpi.com/2077-0383/12/1/246 |
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