Vascular Stem/Progenitor Cells in Vessel Injury and Repair
Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair. Previous studies revealed that myeloid stem/pro...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.845070/full |
| _version_ | 1819284654295875584 |
|---|---|
| author | Jiaping Tao Jiaping Tao Jiaping Tao Xuejie Cao Xuejie Cao Xuejie Cao Baoqi Yu Baoqi Yu Baoqi Yu Aijuan Qu Aijuan Qu Aijuan Qu |
| author_facet | Jiaping Tao Jiaping Tao Jiaping Tao Xuejie Cao Xuejie Cao Xuejie Cao Baoqi Yu Baoqi Yu Baoqi Yu Aijuan Qu Aijuan Qu Aijuan Qu |
| author_sort | Jiaping Tao |
| collection | DOAJ |
| description | Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair. Previous studies revealed that myeloid stem/progenitor cells were the main sources of tissue regeneration after vascular injury. However, accumulating evidences from developing lineage tracing studies indicate that various populations of vessel-resident stem/progenitor cells play specific roles in different process of vessel injury and repair. In response to shear stress, inflammation, or other risk factors-induced vascular injury, these vascular stem/progenitor cells can be activated and consequently differentiate into different types of vascular wall cells to participate in vascular repair. In this review, mechanisms that contribute to stem/progenitor cell differentiation and vascular repair are described. Targeting these mechanisms has potential to improve outcome of diseases that are characterized by vascular injury, such as atherosclerosis, hypertension, restenosis, and aortic aneurysm/dissection. Future studies on potential stem cell-based therapy are also highlighted. |
| first_indexed | 2024-12-24T01:50:49Z |
| format | Article |
| id | doaj.art-2b0894c9ffcd40c8aaa48c1f02a46fd4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-24T01:50:49Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-2b0894c9ffcd40c8aaa48c1f02a46fd42022-12-21T17:21:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-02-01910.3389/fcvm.2022.845070845070Vascular Stem/Progenitor Cells in Vessel Injury and RepairJiaping Tao0Jiaping Tao1Jiaping Tao2Xuejie Cao3Xuejie Cao4Xuejie Cao5Baoqi Yu6Baoqi Yu7Baoqi Yu8Aijuan Qu9Aijuan Qu10Aijuan Qu11Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaThe Key Laboratory of Cardiovascular Remodeling-Related Diseases, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaThe Key Laboratory of Cardiovascular Remodeling-Related Diseases, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaThe Key Laboratory of Cardiovascular Remodeling-Related Diseases, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaThe Key Laboratory of Cardiovascular Remodeling-Related Diseases, Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, ChinaVascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair. Previous studies revealed that myeloid stem/progenitor cells were the main sources of tissue regeneration after vascular injury. However, accumulating evidences from developing lineage tracing studies indicate that various populations of vessel-resident stem/progenitor cells play specific roles in different process of vessel injury and repair. In response to shear stress, inflammation, or other risk factors-induced vascular injury, these vascular stem/progenitor cells can be activated and consequently differentiate into different types of vascular wall cells to participate in vascular repair. In this review, mechanisms that contribute to stem/progenitor cell differentiation and vascular repair are described. Targeting these mechanisms has potential to improve outcome of diseases that are characterized by vascular injury, such as atherosclerosis, hypertension, restenosis, and aortic aneurysm/dissection. Future studies on potential stem cell-based therapy are also highlighted.https://www.frontiersin.org/articles/10.3389/fcvm.2022.845070/fullvascular stem cellsatherosclerosisrestenosishypertensionaortic aneurysmvascular injury |
| spellingShingle | Jiaping Tao Jiaping Tao Jiaping Tao Xuejie Cao Xuejie Cao Xuejie Cao Baoqi Yu Baoqi Yu Baoqi Yu Aijuan Qu Aijuan Qu Aijuan Qu Vascular Stem/Progenitor Cells in Vessel Injury and Repair Frontiers in Cardiovascular Medicine vascular stem cells atherosclerosis restenosis hypertension aortic aneurysm vascular injury |
| title | Vascular Stem/Progenitor Cells in Vessel Injury and Repair |
| title_full | Vascular Stem/Progenitor Cells in Vessel Injury and Repair |
| title_fullStr | Vascular Stem/Progenitor Cells in Vessel Injury and Repair |
| title_full_unstemmed | Vascular Stem/Progenitor Cells in Vessel Injury and Repair |
| title_short | Vascular Stem/Progenitor Cells in Vessel Injury and Repair |
| title_sort | vascular stem progenitor cells in vessel injury and repair |
| topic | vascular stem cells atherosclerosis restenosis hypertension aortic aneurysm vascular injury |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.845070/full |
| work_keys_str_mv | AT jiapingtao vascularstemprogenitorcellsinvesselinjuryandrepair AT jiapingtao vascularstemprogenitorcellsinvesselinjuryandrepair AT jiapingtao vascularstemprogenitorcellsinvesselinjuryandrepair AT xuejiecao vascularstemprogenitorcellsinvesselinjuryandrepair AT xuejiecao vascularstemprogenitorcellsinvesselinjuryandrepair AT xuejiecao vascularstemprogenitorcellsinvesselinjuryandrepair AT baoqiyu vascularstemprogenitorcellsinvesselinjuryandrepair AT baoqiyu vascularstemprogenitorcellsinvesselinjuryandrepair AT baoqiyu vascularstemprogenitorcellsinvesselinjuryandrepair AT aijuanqu vascularstemprogenitorcellsinvesselinjuryandrepair AT aijuanqu vascularstemprogenitorcellsinvesselinjuryandrepair AT aijuanqu vascularstemprogenitorcellsinvesselinjuryandrepair |