Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates
As one of the abundant and inexpensive metals on the earth, copper has demonstrated broad applications in synthetic chemistry and catalysis. Among these copper-catalyzed advances, copper carbenes are versatile and reactive intermediates that can mediate a variety of transformations, which have attra...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/10/3088 |
| _version_ | 1827667549713596416 |
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| author | Kuiyong Dong Mengting Liu Xinfang Xu |
| author_facet | Kuiyong Dong Mengting Liu Xinfang Xu |
| author_sort | Kuiyong Dong |
| collection | DOAJ |
| description | As one of the abundant and inexpensive metals on the earth, copper has demonstrated broad applications in synthetic chemistry and catalysis. Among these copper-catalyzed advances, copper carbenes are versatile and reactive intermediates that can mediate a variety of transformations, which have attracted much attention in the past decades. The present review summarizes two different reaction models that take place between a copper carbene intermediate and alkyne species, including the cross-coupling reaction of copper carbene intermediate with terminal alkyne, and the addition of copper carbene intermediate onto the C–C triple bond. This article will cover the profile from 2010 to 2021 by placing emphasis on the detailed catalytic models and highlighting the synthetic applications offered by these practical and mild methods. |
| first_indexed | 2024-03-10T03:19:54Z |
| format | Article |
| id | doaj.art-2b094916d53a43d3b6f1ee8658f475a5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:19:54Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2b094916d53a43d3b6f1ee8658f475a52023-11-23T12:20:53ZengMDPI AGMolecules1420-30492022-05-012710308810.3390/molecules27103088Recent Advances in Catalytic Alkyne Transformation via Copper Carbene IntermediatesKuiyong Dong0Mengting Liu1Xinfang Xu2School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, ChinaGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaAs one of the abundant and inexpensive metals on the earth, copper has demonstrated broad applications in synthetic chemistry and catalysis. Among these copper-catalyzed advances, copper carbenes are versatile and reactive intermediates that can mediate a variety of transformations, which have attracted much attention in the past decades. The present review summarizes two different reaction models that take place between a copper carbene intermediate and alkyne species, including the cross-coupling reaction of copper carbene intermediate with terminal alkyne, and the addition of copper carbene intermediate onto the C–C triple bond. This article will cover the profile from 2010 to 2021 by placing emphasis on the detailed catalytic models and highlighting the synthetic applications offered by these practical and mild methods.https://www.mdpi.com/1420-3049/27/10/3088copper catalysiscarbene intermediatealkyne functionalizationcross-coupling reactioncyclopropenationcarbene/alkyne metathesis |
| spellingShingle | Kuiyong Dong Mengting Liu Xinfang Xu Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates Molecules copper catalysis carbene intermediate alkyne functionalization cross-coupling reaction cyclopropenation carbene/alkyne metathesis |
| title | Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates |
| title_full | Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates |
| title_fullStr | Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates |
| title_full_unstemmed | Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates |
| title_short | Recent Advances in Catalytic Alkyne Transformation via Copper Carbene Intermediates |
| title_sort | recent advances in catalytic alkyne transformation via copper carbene intermediates |
| topic | copper catalysis carbene intermediate alkyne functionalization cross-coupling reaction cyclopropenation carbene/alkyne metathesis |
| url | https://www.mdpi.com/1420-3049/27/10/3088 |
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