Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P. distasonis ameliorates liver fibrosis in studies with male mice, potentially via altered bile acid metabo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37459-z |
| _version_ | 1827974411989286912 |
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| author | Qi Zhao Man-Yun Dai Ruo-Yue Huang Jing-Yi Duan Ting Zhang Wei-Min Bao Jing-Yi Zhang Shao-Qiang Gui Shu-Min Xia Cong-Ting Dai Ying-Mei Tang Frank J. Gonzalez Fei Li |
| author_facet | Qi Zhao Man-Yun Dai Ruo-Yue Huang Jing-Yi Duan Ting Zhang Wei-Min Bao Jing-Yi Zhang Shao-Qiang Gui Shu-Min Xia Cong-Ting Dai Ying-Mei Tang Frank J. Gonzalez Fei Li |
| author_sort | Qi Zhao |
| collection | DOAJ |
| description | Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P. distasonis ameliorates liver fibrosis in studies with male mice, potentially via altered bile acid metabolism and hepatocyte pyroptosis. |
| first_indexed | 2024-04-09T19:53:57Z |
| format | Article |
| id | doaj.art-2b0a8c1ab8384738af2e1a561d04d40a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:53:57Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2b0a8c1ab8384738af2e1a561d04d40a2023-04-03T05:33:01ZengNature PortfolioNature Communications2041-17232023-04-0114111810.1038/s41467-023-37459-zParabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male miceQi Zhao0Man-Yun Dai1Ruo-Yue Huang2Jing-Yi Duan3Ting Zhang4Wei-Min Bao5Jing-Yi Zhang6Shao-Qiang Gui7Shu-Min Xia8Cong-Ting Dai9Ying-Mei Tang10Frank J. Gonzalez11Fei Li12Laboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityLaboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityLaboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityLaboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityLaboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityDepartment of General Surgery, The First People’s Hospital of Yunnan ProvinceDepartment of Gastroenterology, The second Affiliated Hospital of Kunming Medical UniversityDepartment of Gastroenterology, The second Affiliated Hospital of Kunming Medical UniversityDepartment of Gastroenterology, The second Affiliated Hospital of Kunming Medical UniversityDepartment of Gastroenterology, The second Affiliated Hospital of Kunming Medical UniversityDepartment of Gastroenterology, The second Affiliated Hospital of Kunming Medical UniversityCenter for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Metabolomics and Drug-Induced Liver Injury, Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan UniversityParabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P. distasonis ameliorates liver fibrosis in studies with male mice, potentially via altered bile acid metabolism and hepatocyte pyroptosis.https://doi.org/10.1038/s41467-023-37459-z |
| spellingShingle | Qi Zhao Man-Yun Dai Ruo-Yue Huang Jing-Yi Duan Ting Zhang Wei-Min Bao Jing-Yi Zhang Shao-Qiang Gui Shu-Min Xia Cong-Ting Dai Ying-Mei Tang Frank J. Gonzalez Fei Li Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice Nature Communications |
| title | Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| title_full | Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| title_fullStr | Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| title_full_unstemmed | Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| title_short | Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| title_sort | parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice |
| url | https://doi.org/10.1038/s41467-023-37459-z |
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