Not Just Another Scaffolding Protein Family: The Multifaceted MPPs
Membrane palmitoylated proteins (MPPs) are a subfamily of a larger group of multidomain proteins, namely, membrane-associated guanylate kinases (MAGUKs). The ubiquitous expression and multidomain structure of MPPs provide the ability to form diverse protein complexes at the cell membranes, which are...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/4954 |
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| author | Agnieszka Chytła Weronika Gajdzik-Nowak Paulina Olszewska Agnieszka Biernatowska Aleksander F. Sikorski Aleksander Czogalla |
| author_facet | Agnieszka Chytła Weronika Gajdzik-Nowak Paulina Olszewska Agnieszka Biernatowska Aleksander F. Sikorski Aleksander Czogalla |
| author_sort | Agnieszka Chytła |
| collection | DOAJ |
| description | Membrane palmitoylated proteins (MPPs) are a subfamily of a larger group of multidomain proteins, namely, membrane-associated guanylate kinases (MAGUKs). The ubiquitous expression and multidomain structure of MPPs provide the ability to form diverse protein complexes at the cell membranes, which are involved in a wide range of cellular processes, including establishing the proper cell structure, polarity and cell adhesion. The formation of MPP-dependent complexes in various cell types seems to be based on similar principles, but involves members of different protein groups, such as 4.1-ezrin-radixin-moesin (FERM) domain-containing proteins, polarity proteins or other MAGUKs, showing their multifaceted nature. In this review, we discuss the function of the MPP family in the formation of multiple protein complexes. Notably, we depict their significant role for cell physiology, as the loss of interactions between proteins involved in the complex has a variety of negative consequences. Moreover, based on recent studies concerning the mechanism of membrane raft formation, we shed new light on a possible role played by MPPs in lateral membrane organization. |
| first_indexed | 2024-03-10T15:19:32Z |
| format | Article |
| id | doaj.art-2b0af051b2e34fc49fac0149cb636ca8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:19:32Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2b0af051b2e34fc49fac0149cb636ca82023-11-20T18:35:17ZengMDPI AGMolecules1420-30492020-10-012521495410.3390/molecules25214954Not Just Another Scaffolding Protein Family: The Multifaceted MPPsAgnieszka Chytła0Weronika Gajdzik-Nowak1Paulina Olszewska2Agnieszka Biernatowska3Aleksander F. Sikorski4Aleksander Czogalla5Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, PolandDepartment of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, PolandDepartment of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, PolandDepartment of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, PolandResearch and Development Center, Regional Specialist Hospital, Kamieńskiego 73a, 51-154 Wroclaw, PolandDepartment of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, PolandMembrane palmitoylated proteins (MPPs) are a subfamily of a larger group of multidomain proteins, namely, membrane-associated guanylate kinases (MAGUKs). The ubiquitous expression and multidomain structure of MPPs provide the ability to form diverse protein complexes at the cell membranes, which are involved in a wide range of cellular processes, including establishing the proper cell structure, polarity and cell adhesion. The formation of MPP-dependent complexes in various cell types seems to be based on similar principles, but involves members of different protein groups, such as 4.1-ezrin-radixin-moesin (FERM) domain-containing proteins, polarity proteins or other MAGUKs, showing their multifaceted nature. In this review, we discuss the function of the MPP family in the formation of multiple protein complexes. Notably, we depict their significant role for cell physiology, as the loss of interactions between proteins involved in the complex has a variety of negative consequences. Moreover, based on recent studies concerning the mechanism of membrane raft formation, we shed new light on a possible role played by MPPs in lateral membrane organization.https://www.mdpi.com/1420-3049/25/21/4954membrane palmitoylated protein (MPP)membrane-associated guanylate kinases (MAGUKs)membrane raftscell adhesioncell polarity |
| spellingShingle | Agnieszka Chytła Weronika Gajdzik-Nowak Paulina Olszewska Agnieszka Biernatowska Aleksander F. Sikorski Aleksander Czogalla Not Just Another Scaffolding Protein Family: The Multifaceted MPPs Molecules membrane palmitoylated protein (MPP) membrane-associated guanylate kinases (MAGUKs) membrane rafts cell adhesion cell polarity |
| title | Not Just Another Scaffolding Protein Family: The Multifaceted MPPs |
| title_full | Not Just Another Scaffolding Protein Family: The Multifaceted MPPs |
| title_fullStr | Not Just Another Scaffolding Protein Family: The Multifaceted MPPs |
| title_full_unstemmed | Not Just Another Scaffolding Protein Family: The Multifaceted MPPs |
| title_short | Not Just Another Scaffolding Protein Family: The Multifaceted MPPs |
| title_sort | not just another scaffolding protein family the multifaceted mpps |
| topic | membrane palmitoylated protein (MPP) membrane-associated guanylate kinases (MAGUKs) membrane rafts cell adhesion cell polarity |
| url | https://www.mdpi.com/1420-3049/25/21/4954 |
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