Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study
Background: We sought to explore the potential relationship between serum levels of thyroid hormones with those of androgen and metabolic parameters in women with polycystic ovary syndrome (PCOS). Methods: Data from 1059 Chinese women with PCOS and 1015 healthy women was retrospectively collected. T...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-08-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/8/10.31083/j.ceog5008162 |
| _version_ | 1797733116985475072 |
|---|---|
| author | Manman Pan Jinghua Zhang Qing Zhang Fangfang Wang Fan Qu Mei Jin |
| author_facet | Manman Pan Jinghua Zhang Qing Zhang Fangfang Wang Fan Qu Mei Jin |
| author_sort | Manman Pan |
| collection | DOAJ |
| description | Background: We sought to explore the potential relationship between serum levels of thyroid hormones with those of androgen and metabolic parameters in women with polycystic ovary syndrome (PCOS). Methods: Data from 1059 Chinese women with PCOS and 1015 healthy women was retrospectively collected. This data including fasting glucose and insulin, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), anti-thyroperoxidase antibody (ANTI-TPO), anti-thyroglobulin (ATG), dehydroepiandrosterone sulfate (DHEAS), total testosterone (TTE), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), progesterone (PGN), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). Thyroid-related indicators were compared between PCOS and non-PCOS patients enrolled in this study. Independent variables of PCOS were compared among subgroups in accordance with the classification of TSH, homeostatic model assessment of insulin resistance (HOMA-IR), and TTE levels. To further explore the association between thyroid hormones levels and correlated metabolic parameters in PCOS, multiple regression analyses were conducted. Results: Our study found that PCOS patients had significantly higher serum TSH, FT3, TT3 and TT4 levels than non-PCOS patients. PCOS patients with TSH ≥2.5 mIU/L had significantly higher TG, fasting insulin, HOMA-IR and homeostatic model assessment of β-cell function (HOMA-B), however, these patients also displayed significantly lower DHEAS, HDL, and quantitative insulin sensitivity check index (QUICKI) when compared to patients with TSH levels <2.5 mIU/L. PCOS patients with HOMA-IR levels ≥2.5 mIU/L demonstrated significantly higher FT3 and TSH, but lower TT3 when compared to women with HOMA-IR levels <2.5 mIU/L. Four groups divided by TTE displayed significant differences in FT3 in PCOS patients. Multiple linear regression analysis showed that TSH was significantly negatively associated with DHEAS and QUICKI. Conclusions: TSH levels are closely correlated to the metabolic and endocrine characteristics of PCOS, especially dyslipidemia and insulin resistance. |
| first_indexed | 2024-03-12T12:23:27Z |
| format | Article |
| id | doaj.art-2b0f106a9f2d442a999d91b3b348c2cf |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-12T12:23:27Z |
| publishDate | 2023-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-2b0f106a9f2d442a999d91b3b348c2cf2023-08-30T05:21:34ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-08-0150816210.31083/j.ceog5008162S0390-6663(23)02108-5Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional StudyManman Pan0Jinghua Zhang1Qing Zhang2Fangfang Wang3Fan Qu4Mei Jin5Traditional Chinese Medicine Department, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Clinical Laboratory, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaTraditional Chinese Medicine Department, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaTraditional Chinese Medicine Department, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaTraditional Chinese Medicine Department, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Gynecology, Hangzhou Women's Hospital, 310006 Hangzhou, Zhejiang, ChinaBackground: We sought to explore the potential relationship between serum levels of thyroid hormones with those of androgen and metabolic parameters in women with polycystic ovary syndrome (PCOS). Methods: Data from 1059 Chinese women with PCOS and 1015 healthy women was retrospectively collected. This data including fasting glucose and insulin, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), anti-thyroperoxidase antibody (ANTI-TPO), anti-thyroglobulin (ATG), dehydroepiandrosterone sulfate (DHEAS), total testosterone (TTE), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), progesterone (PGN), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). Thyroid-related indicators were compared between PCOS and non-PCOS patients enrolled in this study. Independent variables of PCOS were compared among subgroups in accordance with the classification of TSH, homeostatic model assessment of insulin resistance (HOMA-IR), and TTE levels. To further explore the association between thyroid hormones levels and correlated metabolic parameters in PCOS, multiple regression analyses were conducted. Results: Our study found that PCOS patients had significantly higher serum TSH, FT3, TT3 and TT4 levels than non-PCOS patients. PCOS patients with TSH ≥2.5 mIU/L had significantly higher TG, fasting insulin, HOMA-IR and homeostatic model assessment of β-cell function (HOMA-B), however, these patients also displayed significantly lower DHEAS, HDL, and quantitative insulin sensitivity check index (QUICKI) when compared to patients with TSH levels <2.5 mIU/L. PCOS patients with HOMA-IR levels ≥2.5 mIU/L demonstrated significantly higher FT3 and TSH, but lower TT3 when compared to women with HOMA-IR levels <2.5 mIU/L. Four groups divided by TTE displayed significant differences in FT3 in PCOS patients. Multiple linear regression analysis showed that TSH was significantly negatively associated with DHEAS and QUICKI. Conclusions: TSH levels are closely correlated to the metabolic and endocrine characteristics of PCOS, especially dyslipidemia and insulin resistance.https://www.imrpress.com/journal/CEOG/50/8/10.31083/j.ceog5008162polycystic ovary syndromethyroid functionandrogeninsulin resistancelipid metabolism |
| spellingShingle | Manman Pan Jinghua Zhang Qing Zhang Fangfang Wang Fan Qu Mei Jin Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study Clinical and Experimental Obstetrics & Gynecology polycystic ovary syndrome thyroid function androgen insulin resistance lipid metabolism |
| title | Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study |
| title_full | Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study |
| title_fullStr | Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study |
| title_full_unstemmed | Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study |
| title_short | Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study |
| title_sort | association of serum thyroid hormone levels with androgen and metabolic parameters in chinese women with polycystic ovary syndrome a retrospective cross sectional study |
| topic | polycystic ovary syndrome thyroid function androgen insulin resistance lipid metabolism |
| url | https://www.imrpress.com/journal/CEOG/50/8/10.31083/j.ceog5008162 |
| work_keys_str_mv | AT manmanpan associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy AT jinghuazhang associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy AT qingzhang associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy AT fangfangwang associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy AT fanqu associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy AT meijin associationofserumthyroidhormonelevelswithandrogenandmetabolicparametersinchinesewomenwithpolycysticovarysyndromearetrospectivecrosssectionalstudy |