Botulinum toxin treatment of lower extremity spasticity
The article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. Gait biomechanics, step cycle and main pathologic patterns of lower extremity are described (hip adduction, knee flexion, knee extension, foot plantar flexion, equinovarus foot...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-11-01
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| Series: | Нервно-мышечные болезни |
| Subjects: | |
| Online Access: | https://nmb.abvpress.ru/jour/article/view/210 |
| _version_ | 1797695476314669056 |
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| author | S. E. Khat’kova M. A. Akulov O. R. Orlova D. Yu. Usachev A. S. Orlova L. V. Krylova |
| author_facet | S. E. Khat’kova M. A. Akulov O. R. Orlova D. Yu. Usachev A. S. Orlova L. V. Krylova |
| author_sort | S. E. Khat’kova |
| collection | DOAJ |
| description | The article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. Gait biomechanics, step cycle and main pathologic patterns of lower extremity are described (hip adduction, knee flexion, knee extension, foot plantar flexion, equinovarus foot position, toes flexion, hallux extension), including muscles involved in the pathological process. Additionally the article contains detailed information on pathologic principles of lower extremity spasticity development. Special focus is given to sarcomeregenesis as an essential element of the development of potential conditions for muscle tissue adaptation to a new state and restoration of muscle length and strength. At present Botulinum toxin A (BTA) is used in a complex spasticity management programs. The results of clinical studies performed in the last decade supporting the efficacy of Botox® (Onabotulinumtoxin A) in the treatment of spasticity are reviewed. Effective BTA doses are proposed. Authors came to the conclusion that BTA as a part of complex rehabilitation in patients with poststroke spasticity of lower extremity promotes treatment efficacy due to a decrease of muscle tone and increase of range of movements in the joints. BTA should be regarded as an essential part of standard rehabilitation programs. Further studies to define optimal muscles for intervention, BTA doses and rehabilitation schemes are still needed. |
| first_indexed | 2024-03-12T03:12:57Z |
| format | Article |
| id | doaj.art-2b0f2a0edca644b4b5c3b6f4d0edcc4f |
| institution | Directory Open Access Journal |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| last_indexed | 2024-03-12T03:12:57Z |
| publishDate | 2017-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj.art-2b0f2a0edca644b4b5c3b6f4d0edcc4f2023-09-03T14:15:44ZrusABV-pressНервно-мышечные болезни2222-87212413-04432017-11-0173213510.17650/2222-8721-2017-7-3-21-35180Botulinum toxin treatment of lower extremity spasticityS. E. Khat’kova0M. A. Akulov1O. R. Orlova2D. Yu. Usachev3A. S. Orlova4L. V. Krylova5ФГАУ «Лечебно-реабилитационный центр» Минздрава России; ФГБУ ГНЦ «Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА РоссииФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава РоссииФГАОУ ВО Первый Московский государственный медицинский университет им. И.И. Сеченова Минздрава РоссииФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава РоссииФГАОУ ВО Первый Московский государственный медицинский университет им. И.И. Сеченова Минздрава РоссииГАУЗ «Госпиталь для ветеранов войн»; Россия, Республика ТатарстанThe article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. Gait biomechanics, step cycle and main pathologic patterns of lower extremity are described (hip adduction, knee flexion, knee extension, foot plantar flexion, equinovarus foot position, toes flexion, hallux extension), including muscles involved in the pathological process. Additionally the article contains detailed information on pathologic principles of lower extremity spasticity development. Special focus is given to sarcomeregenesis as an essential element of the development of potential conditions for muscle tissue adaptation to a new state and restoration of muscle length and strength. At present Botulinum toxin A (BTA) is used in a complex spasticity management programs. The results of clinical studies performed in the last decade supporting the efficacy of Botox® (Onabotulinumtoxin A) in the treatment of spasticity are reviewed. Effective BTA doses are proposed. Authors came to the conclusion that BTA as a part of complex rehabilitation in patients with poststroke spasticity of lower extremity promotes treatment efficacy due to a decrease of muscle tone and increase of range of movements in the joints. BTA should be regarded as an essential part of standard rehabilitation programs. Further studies to define optimal muscles for intervention, BTA doses and rehabilitation schemes are still needed.https://nmb.abvpress.ru/jour/article/view/210нижняя конечностьспастичностьботулинический токсининсультходьбапаттерн спастичности |
| spellingShingle | S. E. Khat’kova M. A. Akulov O. R. Orlova D. Yu. Usachev A. S. Orlova L. V. Krylova Botulinum toxin treatment of lower extremity spasticity Нервно-мышечные болезни нижняя конечность спастичность ботулинический токсин инсульт ходьба паттерн спастичности |
| title | Botulinum toxin treatment of lower extremity spasticity |
| title_full | Botulinum toxin treatment of lower extremity spasticity |
| title_fullStr | Botulinum toxin treatment of lower extremity spasticity |
| title_full_unstemmed | Botulinum toxin treatment of lower extremity spasticity |
| title_short | Botulinum toxin treatment of lower extremity spasticity |
| title_sort | botulinum toxin treatment of lower extremity spasticity |
| topic | нижняя конечность спастичность ботулинический токсин инсульт ходьба паттерн спастичности |
| url | https://nmb.abvpress.ru/jour/article/view/210 |
| work_keys_str_mv | AT sekhatkova botulinumtoxintreatmentoflowerextremityspasticity AT maakulov botulinumtoxintreatmentoflowerextremityspasticity AT ororlova botulinumtoxintreatmentoflowerextremityspasticity AT dyuusachev botulinumtoxintreatmentoflowerextremityspasticity AT asorlova botulinumtoxintreatmentoflowerextremityspasticity AT lvkrylova botulinumtoxintreatmentoflowerextremityspasticity |