TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family
The two members of the UBASH3/STS/TULA protein family have been shown to critically regulate key biological functions, including immunity and hemostasis, in mammalian biological systems. Negative regulation of signaling through immune receptor tyrosine-based activation motif (ITAM)- and hemITAM-bear...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9126 |
| _version_ | 1797597460154023936 |
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| author | Alexander Y. Tsygankov |
| author_facet | Alexander Y. Tsygankov |
| author_sort | Alexander Y. Tsygankov |
| collection | DOAJ |
| description | The two members of the UBASH3/STS/TULA protein family have been shown to critically regulate key biological functions, including immunity and hemostasis, in mammalian biological systems. Negative regulation of signaling through immune receptor tyrosine-based activation motif (ITAM)- and hemITAM-bearing receptors mediated by Syk-family protein tyrosine kinases appears to be a major molecular mechanism of the down-regulatory effect of TULA-family proteins, which possess protein tyrosine phosphatase (PTP) activity. However, these proteins are likely to carry out some PTP-independent functions as well. Whereas the effects of TULA-family proteins overlap, their characteristics and their individual contributions to cellular regulation also demonstrate clearly distinct features. Protein structure, enzymatic activity, molecular mechanisms of regulation, and biological functions of TULA-family proteins are discussed in this review. In particular, the usefulness of the comparative analysis of TULA proteins in various metazoan taxa, for identifying potential roles of TULA-family proteins outside of their functions already established in mammalian systems, is examined. |
| first_indexed | 2024-03-11T03:06:23Z |
| format | Article |
| id | doaj.art-2b115646c93e45e6946bfbc213275742 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2b115646c93e45e6946bfbc2132757422023-11-18T07:54:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411912610.3390/ijms24119126TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the FamilyAlexander Y. Tsygankov0Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USAThe two members of the UBASH3/STS/TULA protein family have been shown to critically regulate key biological functions, including immunity and hemostasis, in mammalian biological systems. Negative regulation of signaling through immune receptor tyrosine-based activation motif (ITAM)- and hemITAM-bearing receptors mediated by Syk-family protein tyrosine kinases appears to be a major molecular mechanism of the down-regulatory effect of TULA-family proteins, which possess protein tyrosine phosphatase (PTP) activity. However, these proteins are likely to carry out some PTP-independent functions as well. Whereas the effects of TULA-family proteins overlap, their characteristics and their individual contributions to cellular regulation also demonstrate clearly distinct features. Protein structure, enzymatic activity, molecular mechanisms of regulation, and biological functions of TULA-family proteins are discussed in this review. In particular, the usefulness of the comparative analysis of TULA proteins in various metazoan taxa, for identifying potential roles of TULA-family proteins outside of their functions already established in mammalian systems, is examined.https://www.mdpi.com/1422-0067/24/11/9126TULATULA-1TULA-2Sts-1Sts-2UBASH3A |
| spellingShingle | Alexander Y. Tsygankov TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family International Journal of Molecular Sciences TULA TULA-1 TULA-2 Sts-1 Sts-2 UBASH3A |
| title | TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family |
| title_full | TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family |
| title_fullStr | TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family |
| title_full_unstemmed | TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family |
| title_short | TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family |
| title_sort | tula proteins in men mice hens and lice welcome to the family |
| topic | TULA TULA-1 TULA-2 Sts-1 Sts-2 UBASH3A |
| url | https://www.mdpi.com/1422-0067/24/11/9126 |
| work_keys_str_mv | AT alexanderytsygankov tulaproteinsinmenmicehensandlicewelcometothefamily |