Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension
Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/5/1006 |
| _version_ | 1827742254731624448 |
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| author | Paula Poyatos Miquel Gratacós Kay Samuel Ramon Orriols Olga Tura-Ceide |
| author_facet | Paula Poyatos Miquel Gratacós Kay Samuel Ramon Orriols Olga Tura-Ceide |
| author_sort | Paula Poyatos |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology. Alteration of redox homeostasis produces excessive generation of reactive oxygen species, inducing oxidative stress and the subsequent alteration of biological molecules. Exacerbations in oxidative stress production can lead to alterations in nitric oxide signaling pathways, contributing to the proliferation of pulmonary arterial endothelial cells and smooth muscle cells, inducing PH development. Recently, antioxidant therapy has been suggested as a novel therapeutic strategy for PH pathology. However, the favorable outcomes observed in preclinical studies have not been consistently reproduced in clinical practice. Therefore, targeting oxidative stress as a therapeutic intervention for PH is an area that is still being explored. This review summarizes the contribution of oxidative stress to the pathogenesis of the different types of PH and suggests antioxidant therapy as a promising strategy for PH treatment. |
| first_indexed | 2024-03-11T03:59:22Z |
| format | Article |
| id | doaj.art-2b11e5f542d941079a4321b6956e6d3f |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T03:59:22Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2b11e5f542d941079a4321b6956e6d3f2023-11-18T00:14:05ZengMDPI AGAntioxidants2076-39212023-04-01125100610.3390/antiox12051006Oxidative Stress and Antioxidant Therapy in Pulmonary HypertensionPaula Poyatos0Miquel Gratacós1Kay Samuel2Ramon Orriols3Olga Tura-Ceide4Department of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institute (IDIBGI), 17190 Girona, SpainDepartment of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institute (IDIBGI), 17190 Girona, SpainScottish National Blood Transfusion Service, NHS National Services Scotland, Edinburgh EH14 4BE, UKDepartment of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institute (IDIBGI), 17190 Girona, SpainDepartment of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institute (IDIBGI), 17190 Girona, SpainPulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology. Alteration of redox homeostasis produces excessive generation of reactive oxygen species, inducing oxidative stress and the subsequent alteration of biological molecules. Exacerbations in oxidative stress production can lead to alterations in nitric oxide signaling pathways, contributing to the proliferation of pulmonary arterial endothelial cells and smooth muscle cells, inducing PH development. Recently, antioxidant therapy has been suggested as a novel therapeutic strategy for PH pathology. However, the favorable outcomes observed in preclinical studies have not been consistently reproduced in clinical practice. Therefore, targeting oxidative stress as a therapeutic intervention for PH is an area that is still being explored. This review summarizes the contribution of oxidative stress to the pathogenesis of the different types of PH and suggests antioxidant therapy as a promising strategy for PH treatment.https://www.mdpi.com/2076-3921/12/5/1006pulmonary hypertensionoxidative stressantioxidant therapyendothelial dysfunction |
| spellingShingle | Paula Poyatos Miquel Gratacós Kay Samuel Ramon Orriols Olga Tura-Ceide Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension Antioxidants pulmonary hypertension oxidative stress antioxidant therapy endothelial dysfunction |
| title | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
| title_full | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
| title_fullStr | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
| title_full_unstemmed | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
| title_short | Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension |
| title_sort | oxidative stress and antioxidant therapy in pulmonary hypertension |
| topic | pulmonary hypertension oxidative stress antioxidant therapy endothelial dysfunction |
| url | https://www.mdpi.com/2076-3921/12/5/1006 |
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