The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as huma...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-06-01
|
| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520351725 |
| _version_ | 1818417757310418944 |
|---|---|
| author | Aldons J. Lusis Marcus M. Seldin Hooman Allayee Brian J. Bennett Mete Civelek Richard C. Davis Eleazar Eskin Charles R. Farber Simon Hui Margarete Mehrabian Frode Norheim Calvin Pan Brian Parks Christoph D. Rau Desmond J. Smith Thomas Vallim Yibin Wang Jessica Wang |
| author_facet | Aldons J. Lusis Marcus M. Seldin Hooman Allayee Brian J. Bennett Mete Civelek Richard C. Davis Eleazar Eskin Charles R. Farber Simon Hui Margarete Mehrabian Frode Norheim Calvin Pan Brian Parks Christoph D. Rau Desmond J. Smith Thomas Vallim Yibin Wang Jessica Wang |
| author_sort | Aldons J. Lusis |
| collection | DOAJ |
| description | The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions. |
| first_indexed | 2024-12-14T12:11:51Z |
| format | Article |
| id | doaj.art-2b1437dd97184028a39a17b825fbb20f |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T12:11:51Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-2b1437dd97184028a39a17b825fbb20f2022-12-21T23:01:43ZengElsevierJournal of Lipid Research0022-22752016-06-01576925942The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traitsAldons J. Lusis0Marcus M. Seldin1Hooman Allayee2Brian J. Bennett3Mete Civelek4Richard C. Davis5Eleazar Eskin6Charles R. Farber7Simon Hui8Margarete Mehrabian9Frode Norheim10Calvin Pan11Brian Parks12Christoph D. Rau13Desmond J. Smith14Thomas Vallim15Yibin Wang16Jessica Wang17Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; Microbiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; To whom correspondence should be addressedDepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CADepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CADepartment of Genetics, University of North Carolina, Chapel Hill, NCDepartments of Biomedical Engineering University of Virginia, Charlottesville, VADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CADepartments of Computer Science, University of California-Los Angeles, Los Angeles, CAPublic Health Sciences, University of Virginia, Charlottesville, VADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CAHuman Genetics, University of California-Los Angeles, Los Angeles, CADepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WIAnesthesiology, University of California-Los Angeles, Los Angeles, CAMolecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CAAnesthesiology, University of California-Los Angeles, Los Angeles, CADepartments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CAThe Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.http://www.sciencedirect.com/science/article/pii/S0022227520351725aherosclerosisosteoporosisobesityheart failuremicrobiotagene-by-diet interaction |
| spellingShingle | Aldons J. Lusis Marcus M. Seldin Hooman Allayee Brian J. Bennett Mete Civelek Richard C. Davis Eleazar Eskin Charles R. Farber Simon Hui Margarete Mehrabian Frode Norheim Calvin Pan Brian Parks Christoph D. Rau Desmond J. Smith Thomas Vallim Yibin Wang Jessica Wang The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits Journal of Lipid Research aherosclerosis osteoporosis obesity heart failure microbiota gene-by-diet interaction |
| title | The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits |
| title_full | The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits |
| title_fullStr | The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits |
| title_full_unstemmed | The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits |
| title_short | The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits |
| title_sort | hybrid mouse diversity panel a resource for systems genetics analyses of metabolic and cardiovascular traits |
| topic | aherosclerosis osteoporosis obesity heart failure microbiota gene-by-diet interaction |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520351725 |
| work_keys_str_mv | AT aldonsjlusis thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT marcusmseldin thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT hoomanallayee thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT brianjbennett thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT metecivelek thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT richardcdavis thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT eleazareskin thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT charlesrfarber thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT simonhui thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT margaretemehrabian thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT frodenorheim thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT calvinpan thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT brianparks thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT christophdrau thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT desmondjsmith thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT thomasvallim thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT yibinwang thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT jessicawang thehybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT aldonsjlusis hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT marcusmseldin hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT hoomanallayee hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT brianjbennett hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT metecivelek hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT richardcdavis hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT eleazareskin hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT charlesrfarber hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT simonhui hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT margaretemehrabian hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT frodenorheim hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT calvinpan hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT brianparks hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT christophdrau hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT desmondjsmith hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT thomasvallim hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT yibinwang hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits AT jessicawang hybridmousediversitypanelaresourceforsystemsgeneticsanalysesofmetabolicandcardiovasculartraits |