Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i>
Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R). When cAMP binds the PKA-R subunits, the PKA-C subunits are released and interact with downstr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1878 |
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| author | Fereshteh Sadeghian Perla G. Castaneda Mustafi R. Amin Erin J. Cram |
| author_facet | Fereshteh Sadeghian Perla G. Castaneda Mustafi R. Amin Erin J. Cram |
| author_sort | Fereshteh Sadeghian |
| collection | DOAJ |
| description | Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R). When cAMP binds the PKA-R subunits, the PKA-C subunits are released and interact with downstream effectors. In <i>Caenorhabditis elegans</i> (<i>C. elegans</i>), PKA-C and PKA-R are encoded by <i>kin-1</i> and <i>kin-2,</i> respectively. This review focuses on the contributions of work in <i>C. elegans</i> to our understanding of the many roles of PKA, including contractility and oocyte maturation in the reproductive system, lipid metabolism, physiology, mitochondrial function and lifespan, and a wide variety of behaviors. <i>C. elegans</i> provides a powerful genetic platform for understanding how this kinase can regulate an astounding variety of physiological responses. |
| first_indexed | 2024-03-09T18:12:33Z |
| format | Article |
| id | doaj.art-2b14df5a5de942bd9b1f3909945301d3 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:12:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-2b14df5a5de942bd9b1f3909945301d32023-11-24T08:57:24ZengMDPI AGLife2075-17292022-11-011211187810.3390/life12111878Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i>Fereshteh Sadeghian0Perla G. Castaneda1Mustafi R. Amin2Erin J. Cram3Department of Bioengineering, Northeastern University, Boston, MA 02115, USADepartment of Biology, Northeastern University, Boston, MA 02115, USADepartment of Biology, Northeastern University, Boston, MA 02115, USADepartment of Biology, Northeastern University, Boston, MA 02115, USAProtein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R). When cAMP binds the PKA-R subunits, the PKA-C subunits are released and interact with downstream effectors. In <i>Caenorhabditis elegans</i> (<i>C. elegans</i>), PKA-C and PKA-R are encoded by <i>kin-1</i> and <i>kin-2,</i> respectively. This review focuses on the contributions of work in <i>C. elegans</i> to our understanding of the many roles of PKA, including contractility and oocyte maturation in the reproductive system, lipid metabolism, physiology, mitochondrial function and lifespan, and a wide variety of behaviors. <i>C. elegans</i> provides a powerful genetic platform for understanding how this kinase can regulate an astounding variety of physiological responses.https://www.mdpi.com/2075-1729/12/11/1878PKAcAMPcalcium signaling<i>C. elegans</i>physiologybehavior |
| spellingShingle | Fereshteh Sadeghian Perla G. Castaneda Mustafi R. Amin Erin J. Cram Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> Life PKA cAMP calcium signaling <i>C. elegans</i> physiology behavior |
| title | Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> |
| title_full | Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> |
| title_fullStr | Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> |
| title_full_unstemmed | Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> |
| title_short | Functional Insights into Protein Kinase A (PKA) Signaling from <i>C. elegans</i> |
| title_sort | functional insights into protein kinase a pka signaling from i c elegans i |
| topic | PKA cAMP calcium signaling <i>C. elegans</i> physiology behavior |
| url | https://www.mdpi.com/2075-1729/12/11/1878 |
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