Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model
Abstract The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57611-z |
| _version_ | 1797247317995159552 |
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| author | Dong-Cheol Baek Ji-Yun Kang Jin-Seok Lee Eun-Jung Lee Chang-Gue Son |
| author_facet | Dong-Cheol Baek Ji-Yun Kang Jin-Seok Lee Eun-Jung Lee Chang-Gue Son |
| author_sort | Dong-Cheol Baek |
| collection | DOAJ |
| description | Abstract The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesic behaviors. C57BL/6J female mice were ovariectomized (OVX) to establish a menopausal condition. Along with behavior tests (anxiety, depression, and memory), the expression of ERs, microglial activity, and neuronal activity was measured in six brain regions (hippocampus, prefrontal cortex, striatum, raphe nucleus, amygdala, and hypothalamus) from 4 to 12 weeks after OVX. Mice exhibited anxiety- and depressive-like behaviors, as well as memory impairment. These behavioral alterations have been linked to a suppression in the expression of ERβ. The decreased ERβ expression coincided with microglial-derived neuroinflammation, as indicated by notable activations of Ionized calcium-binding adapter molecule 1 and Interleukin-1beta. Additionally, the activity of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus, decreased in a time-dependent manner from 4 to 12 weeks post-OVX. Our study provides evidence shedding light on the susceptibility to memory impairment and depression in women after menopause. This susceptibility is associated with the suppression of ERβ and alteration of ERα in six brain regions. |
| first_indexed | 2024-04-24T19:56:47Z |
| format | Article |
| id | doaj.art-2b17db4636af4fceb70d49ee5761aa80 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:56:47Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2b17db4636af4fceb70d49ee5761aa802024-03-24T12:16:16ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-57611-zLinking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse modelDong-Cheol Baek0Ji-Yun Kang1Jin-Seok Lee2Eun-Jung Lee3Chang-Gue Son4Institute of Bioscience & Integrative Medicine, Daejeon Korean Hospital of Daejeon UniversityInstitute of Bioscience & Integrative Medicine, Daejeon Korean Hospital of Daejeon UniversityInstitute of Bioscience & Integrative Medicine, Daejeon Korean Hospital of Daejeon UniversityDepartment of Korean Rehabilitation Medicine, Daejeon Korean Hospital of Daejeon UniversityInstitute of Bioscience & Integrative Medicine, Daejeon Korean Hospital of Daejeon UniversityAbstract The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesic behaviors. C57BL/6J female mice were ovariectomized (OVX) to establish a menopausal condition. Along with behavior tests (anxiety, depression, and memory), the expression of ERs, microglial activity, and neuronal activity was measured in six brain regions (hippocampus, prefrontal cortex, striatum, raphe nucleus, amygdala, and hypothalamus) from 4 to 12 weeks after OVX. Mice exhibited anxiety- and depressive-like behaviors, as well as memory impairment. These behavioral alterations have been linked to a suppression in the expression of ERβ. The decreased ERβ expression coincided with microglial-derived neuroinflammation, as indicated by notable activations of Ionized calcium-binding adapter molecule 1 and Interleukin-1beta. Additionally, the activity of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus, decreased in a time-dependent manner from 4 to 12 weeks post-OVX. Our study provides evidence shedding light on the susceptibility to memory impairment and depression in women after menopause. This susceptibility is associated with the suppression of ERβ and alteration of ERα in six brain regions.https://doi.org/10.1038/s41598-024-57611-z |
| spellingShingle | Dong-Cheol Baek Ji-Yun Kang Jin-Seok Lee Eun-Jung Lee Chang-Gue Son Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model Scientific Reports |
| title | Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| title_full | Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| title_fullStr | Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| title_full_unstemmed | Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| title_short | Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| title_sort | linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model |
| url | https://doi.org/10.1038/s41598-024-57611-z |
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