Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production

Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production

Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature (1–3) and three known compounds (4–6). Their structures were e...

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Bibliographic Details
Main Authors: Jongmin Ahn, Yihua Pei, Hee-Sung Chae, Seong-Hwan Kim, Young-Mi Kim, Young Hee Choi, Joongku Lee, Minsun Chang, Yun Seon Song, Roberto Rodriguez, Dong-Chan Oh, Jinwoong Kim, Sangho Choi, Sang Hoon Joo, Young-Won Chin
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
Larrea nitida
spiroketones
biphenyl analog
HMC-1
IL-6
Online Access:http://www.mdpi.com/1420-3049/23/2/302

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