Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

Two epigenetic pathways of transcriptional repression, DNA methylation and polycomb repressive complex 2 (PRC2), are known to regulate neuronal development and function. However, their respective contributions to brain maturation are unknown. We found that conditional loss of the de novo DNA methylt...

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Bibliographic Details
Main Authors: Junhao Li, Antonio Pinto-Duarte, Mark Zander, Michael S Cuoco, Chi-Yu Lai, Julia Osteen, Linjing Fang, Chongyuan Luo, Jacinta D Lucero, Rosa Gomez-Castanon, Joseph R Nery, Isai Silva-Garcia, Yan Pang, Terrence J Sejnowski, Susan B Powell, Joseph R Ecker, Eran A Mukamel, M Margarita Behrens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
epigenetics
synapse
brain development
DNA methylation
Dnmt3a
H3K27me3
Online Access:https://elifesciences.org/articles/66909

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