Tissue-specific effects of targeted mutation of Mir29b1 in ratsResearch in context

Tissue-specific effects of targeted mutation of Mir29b1 in ratsResearch in context

Background: miR-29 is a master regulator of extracellular matrix genes, but conflicting data on its anti-fibrotic effect have been reported. miR-29 improves nitric oxide (NO) production in arterioles by targeting Lypla1. Mir29b1 targeted mutation exacerbates hypertension in a model derived from the...

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Bibliographic Details
Main Authors:	Hong Xue, Guangyuan Zhang, Aron M. Geurts, Kristie Usa, David M. Jensen, Yong Liu, Michael E. Widlansky, Mingyu Liang
Format:	Article
Language:	English
Published:	Elsevier 2018-09-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396418303025

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