The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Abstract The mitochondrial deoxynucleotide triphosphate (dNTP) is maintained by the mitochondrial deoxynucleoside salvage pathway and dedicated for the mtDNA homeostasis, and the mitochondrial deoxyguanosine kinase (DGUOK) is a rate‐limiting enzyme in this pathway. Here, we investigated the role of...

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Bibliographic Details
Main Authors: Shengchen Lin, Chongbiao Huang, Jianwei Sun, Oana Bollt, Xiuchao Wang, Eric Martine, Jiaxin Kang, Matthew D Taylor, Bin Fang, Pankaj K Singh, John Koomen, Jihui Hao, Shengyu Yang
Format: Article
Language:English
Published: Springer Nature 2019-12-01
Series:EMBO Molecular Medicine
Subjects:
cancer stem cell
DGUOK
lung cancer
metastasis
mitochondria
Online Access:https://doi.org/10.15252/emmm.201910849

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