Hepatoprotective effect of Helicanthus elastica
Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of Helicanthus elastica were s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2016-05-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/26149 |
| _version_ | 1818364130896117760 |
|---|---|
| author | K. N. Sunil Kumar R. Rajakrishnan J. Thomas G. Aadinaath Reddy |
| author_facet | K. N. Sunil Kumar R. Rajakrishnan J. Thomas G. Aadinaath Reddy |
| author_sort | K. N. Sunil Kumar |
| collection | DOAJ |
| description | Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of Helicanthus elastica were subjected to acute oral toxicity. The aqueous and ethanolic extract revealed no observable changes in the rats up to the dose level of 2,000 mg /kg body weight. The extracts were then screened for paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD50 based on toxicity study). The aqueous extract of whole plant of H. elastica was found to produce significant (p<0.05) reversal of the paracetamol-induced changes in the measured biochemical and histopathological parameters at lower dose of 200 mg/kg which was found to be better than ethanol extract at the same dose level.
Video Clip of Methodology:
Acute toxicity study and others: 5 min 38 sec Full Screen Alternate |
| first_indexed | 2024-12-13T21:59:29Z |
| format | Article |
| id | doaj.art-2b1f8769129849dd98514601fa973109 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-13T21:59:29Z |
| publishDate | 2016-05-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-2b1f8769129849dd98514601fa9731092022-12-21T23:30:02ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-05-0111210.3329/bjp.v11i2.26149Hepatoprotective effect of Helicanthus elasticaK. N. Sunil Kumar0R. Rajakrishnan1J. Thomas2G. Aadinaath Reddy3Department of Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Laxminarayana Nagar, Kuthpady, Udupi 574-118Deparment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11-451Deparment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11-451Department of Pharmacology, Siddha Central Research Institute, Arignar Anna Govt. Hospital Campus, Arumbakkam, Chennai 600-106Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of Helicanthus elastica were subjected to acute oral toxicity. The aqueous and ethanolic extract revealed no observable changes in the rats up to the dose level of 2,000 mg /kg body weight. The extracts were then screened for paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD50 based on toxicity study). The aqueous extract of whole plant of H. elastica was found to produce significant (p<0.05) reversal of the paracetamol-induced changes in the measured biochemical and histopathological parameters at lower dose of 200 mg/kg which was found to be better than ethanol extract at the same dose level. Video Clip of Methodology: Acute toxicity study and others: 5 min 38 sec Full Screen Alternatehttps://www.banglajol.info/index.php/BJP/article/view/26149Helicanthus elasticaHepatoprotective |
| spellingShingle | K. N. Sunil Kumar R. Rajakrishnan J. Thomas G. Aadinaath Reddy Hepatoprotective effect of Helicanthus elastica Bangladesh Journal of Pharmacology Helicanthus elastica Hepatoprotective |
| title | Hepatoprotective effect of Helicanthus elastica |
| title_full | Hepatoprotective effect of Helicanthus elastica |
| title_fullStr | Hepatoprotective effect of Helicanthus elastica |
| title_full_unstemmed | Hepatoprotective effect of Helicanthus elastica |
| title_short | Hepatoprotective effect of Helicanthus elastica |
| title_sort | hepatoprotective effect of helicanthus elastica |
| topic | Helicanthus elastica Hepatoprotective |
| url | https://www.banglajol.info/index.php/BJP/article/view/26149 |
| work_keys_str_mv | AT knsunilkumar hepatoprotectiveeffectofhelicanthuselastica AT rrajakrishnan hepatoprotectiveeffectofhelicanthuselastica AT jthomas hepatoprotectiveeffectofhelicanthuselastica AT gaadinaathreddy hepatoprotectiveeffectofhelicanthuselastica |