Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population
Danfeng Wang,1,2 Shuhui Min,1,2 Xiao Lin,1,2 Guan Jiang1,2 1Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2First Clinical Medical College, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Guan Jiang, Depar...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-among-mif-ifih1-and-il6-gene-polymorphisms-and-non-segment-peer-reviewed-fulltext-article-CCID |
| _version_ | 1828438129517789184 |
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| author | Wang D Min S Lin X Jiang G |
| author_facet | Wang D Min S Lin X Jiang G |
| author_sort | Wang D |
| collection | DOAJ |
| description | Danfeng Wang,1,2 Shuhui Min,1,2 Xiao Lin,1,2 Guan Jiang1,2 1Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2First Clinical Medical College, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Guan Jiang, Department of Dermatology, Affiliated Hospital of Xuzhou Medical University; First Clinical Medical College, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email dr.guanjiang@xzhmu.edu.cnObjective: The aim of the present study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the macrophage migration inhibiting factor (MIF), interferon-induced Helicase C domain 1 (IFIH1), interleukin-6 (IL6) genes, circulating levels with non-segmental vitiligo (NSV) susceptibility in the Chinese population, and to analyze the relationships between gene polymorphisms and clinical characteristics of vitiligo.Methods: In this study, genotyping was conducted in 155 patients with NSV and 117 unaffected controls using polymerase chain reaction and snapshot technique. Serum concentrations were determined by ELISA kit.Results: There were strong associations between IFIH1 H843R and IL6-572G/C polymorphisms and NSV susceptibility (p = 0.013; p = 0.009). In contrast to previous studies, we found no significant difference in the MIF-173G/C polymorphism between the two groups. In addition, the frequency of allelic distribution for MIF-173G/C in patients with active NSV was significantly higher than stable NSV (p = 0.011), and IFIH1 H843R with early-onset (≤ 20), active or family history of NSV was significantly higher than late-onset (> 20), stable or no family history of NSV (p = 0.033; p = 0.045; p = 0.039). Serum concentrations of MIF were higher in patients with active NSV, serum IFIH1 and IL6 concentrations were related to the presence of polymorphisms in patients with NSV (p = 0.009; p = 0.011).Conclusion: Our results suggested that IFIH1 H843R and IL6-572G/C gene polymorphisms and expression levels are obviously correlated with the onset of NSV. MIF-173G/C allele and serum concentrations may be associated with active NSV, and IFIH1 H843R allele may be associated with youth, active or family history of NSV.Keywords: vitiligo, MIF, IFIH1, IL6, single nucleotide polymorphism |
| first_indexed | 2024-12-10T19:58:38Z |
| format | Article |
| id | doaj.art-2b1fc53ef49841899ab17e738f558497 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-10T19:58:38Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-2b1fc53ef49841899ab17e738f5584972022-12-22T01:35:35ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-08-01Volume 151597160977261Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han PopulationWang DMin SLin XJiang GDanfeng Wang,1,2 Shuhui Min,1,2 Xiao Lin,1,2 Guan Jiang1,2 1Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2First Clinical Medical College, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Guan Jiang, Department of Dermatology, Affiliated Hospital of Xuzhou Medical University; First Clinical Medical College, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email dr.guanjiang@xzhmu.edu.cnObjective: The aim of the present study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the macrophage migration inhibiting factor (MIF), interferon-induced Helicase C domain 1 (IFIH1), interleukin-6 (IL6) genes, circulating levels with non-segmental vitiligo (NSV) susceptibility in the Chinese population, and to analyze the relationships between gene polymorphisms and clinical characteristics of vitiligo.Methods: In this study, genotyping was conducted in 155 patients with NSV and 117 unaffected controls using polymerase chain reaction and snapshot technique. Serum concentrations were determined by ELISA kit.Results: There were strong associations between IFIH1 H843R and IL6-572G/C polymorphisms and NSV susceptibility (p = 0.013; p = 0.009). In contrast to previous studies, we found no significant difference in the MIF-173G/C polymorphism between the two groups. In addition, the frequency of allelic distribution for MIF-173G/C in patients with active NSV was significantly higher than stable NSV (p = 0.011), and IFIH1 H843R with early-onset (≤ 20), active or family history of NSV was significantly higher than late-onset (> 20), stable or no family history of NSV (p = 0.033; p = 0.045; p = 0.039). Serum concentrations of MIF were higher in patients with active NSV, serum IFIH1 and IL6 concentrations were related to the presence of polymorphisms in patients with NSV (p = 0.009; p = 0.011).Conclusion: Our results suggested that IFIH1 H843R and IL6-572G/C gene polymorphisms and expression levels are obviously correlated with the onset of NSV. MIF-173G/C allele and serum concentrations may be associated with active NSV, and IFIH1 H843R allele may be associated with youth, active or family history of NSV.Keywords: vitiligo, MIF, IFIH1, IL6, single nucleotide polymorphismhttps://www.dovepress.com/association-among-mif-ifih1-and-il6-gene-polymorphisms-and-non-segment-peer-reviewed-fulltext-article-CCIDvitiligomififih1il6single nucleotide polymorphism |
| spellingShingle | Wang D Min S Lin X Jiang G Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population Clinical, Cosmetic and Investigational Dermatology vitiligo mif ifih1 il6 single nucleotide polymorphism |
| title | Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population |
| title_full | Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population |
| title_fullStr | Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population |
| title_full_unstemmed | Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population |
| title_short | Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population |
| title_sort | association among mif ifih1 and il6 gene polymorphisms and non segmental vitiligo in a chinese han population |
| topic | vitiligo mif ifih1 il6 single nucleotide polymorphism |
| url | https://www.dovepress.com/association-among-mif-ifih1-and-il6-gene-polymorphisms-and-non-segment-peer-reviewed-fulltext-article-CCID |
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