An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease
Background: Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). Patients and Methods: We measured the silent period (SP) induced by transcranial magnetic stimulation in AD patients in the very...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-11-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/367841 |
| _version_ | 1818584434288361472 |
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| author | Christina Balla Alain Maertens de Noordhout Jean Louis Pepin |
| author_facet | Christina Balla Alain Maertens de Noordhout Jean Louis Pepin |
| author_sort | Christina Balla |
| collection | DOAJ |
| description | Background: Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). Patients and Methods: We measured the silent period (SP) induced by transcranial magnetic stimulation in AD patients in the very early stage of the disease, and we explored whether and in which way the pharmacologic manipulation of the cholinergic system could modify it. Results: An increase in the duration of the SP was observed in AD patients in the early stage in comparison to controls. After 2 months of treatment with donepezil, the duration did not differ significantly from that of normal subjects. The results of our study show a fragmentation and an enlargement of the SP in the presence of multiple late excitatory potentials (LEPs) in early untreated AD patients. These LEPs were also modulated by donepezil. Conclusions: The results suggest an early functional impairment of cholinergic neurotransmission in AD. The disturbance in acetylcholine output in early AD leads to a decrease in excitability of the motor system. |
| first_indexed | 2024-12-16T08:21:07Z |
| format | Article |
| id | doaj.art-2b20c83105984de9bf8190ef48d5c2dd |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-16T08:21:07Z |
| publishDate | 2014-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-2b20c83105984de9bf8190ef48d5c2dd2022-12-21T22:38:06ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642014-11-014345746410.1159/000367841367841An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's DiseaseChristina BallaAlain Maertens de NoordhoutJean Louis PepinBackground: Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). Patients and Methods: We measured the silent period (SP) induced by transcranial magnetic stimulation in AD patients in the very early stage of the disease, and we explored whether and in which way the pharmacologic manipulation of the cholinergic system could modify it. Results: An increase in the duration of the SP was observed in AD patients in the early stage in comparison to controls. After 2 months of treatment with donepezil, the duration did not differ significantly from that of normal subjects. The results of our study show a fragmentation and an enlargement of the SP in the presence of multiple late excitatory potentials (LEPs) in early untreated AD patients. These LEPs were also modulated by donepezil. Conclusions: The results suggest an early functional impairment of cholinergic neurotransmission in AD. The disturbance in acetylcholine output in early AD leads to a decrease in excitability of the motor system.http://www.karger.com/Article/FullText/367841Transcranial magnetic stimulationAlzheimer’s disease |
| spellingShingle | Christina Balla Alain Maertens de Noordhout Jean Louis Pepin An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease Dementia and Geriatric Cognitive Disorders Extra Transcranial magnetic stimulation Alzheimer’s disease |
| title | An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease |
| title_full | An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease |
| title_fullStr | An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease |
| title_full_unstemmed | An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease |
| title_short | An Investigation of the Late Excitatory Potentials in the Hand following Transcranial Magnetic Stimulation in Early Alzheimer's Disease |
| title_sort | investigation of the late excitatory potentials in the hand following transcranial magnetic stimulation in early alzheimer s disease |
| topic | Transcranial magnetic stimulation Alzheimer’s disease |
| url | http://www.karger.com/Article/FullText/367841 |
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